Nucific Bio X4
Nkotaiat flowers Acmella (installations toothache, Paracress) is a food products that contain little of the history of medicinal use in connection with the ease her pain characteristics. As biologically active accommodate topically and leaves are used in power, it has been touted power consumption to help toothaches and other diseases of the mouth where the pain is a side effect to it.It is currently in the initial stages of the investigation at this time, there is no human guide. In rats, these effects to ease the pain does not seem to exist when applied to the skin (no evidence of consumption by mouth) which is very strong, but poor performance compared with the reference medicine.
Other properties Spilanthese Acmella aphrodisiac (which seems to be very strong in mice, and the accumulation of the effectiveness with the passage of time, rather than acute effects) and the effect of a diuretic, so it makes only a study on the effects of day, but showed more strength than furosemide. Diuresis mechanism appears to be similar to a class of diuretics.
In addition, Nkotaiat flowers were found to increase testosterone, FSH, LH and. Also similar effects have been observed with another herb that has the same molecular class of N-Akylamides (pyrethrum), but now this is a study.
What You Should Know
Also known as
Jampio some plants, Acmella OLERACEA, Nkotaiat flowers OLERACEA toothache plant, Paracress
Things to consider
Most biologically active in Nkotaiat flowers Acmella show polar high and you may need to be absorbed into food
It is a form of
Testosterone Booster
Aphrodisiac
Notice of caution
Examine.com Medical Disclaimer
Taking (the recommended dose, active and quantities, and other details)
Based on the test in mice using 150 mg / kg of ethanol extract an estimated human dose:
Nkotaiat flowers acmella is the most common plant Acmella OLERACEA name (and his last name OLERACEA Nkotaiat flowers, which uses a lot less too). He belongs to the plant family Astrassaa, and used in Ayurveda. [1]
It includes common terminology used to refer to Jampio station, toothache or Paracress factory. Sometimes the plant is used, "toothache" name of "spilanthol" complex to reduce the pain associated with pain in the teeth and can stimulate the secretion of saliva, [2] is derived, along with the other Acmellonate complex. [3 traditional] other uses of this herb in Indian medicine and the treatment of rheumatism and arthritis, and diuretic saliva for stuttering, tongue paralysis, inflammation of the mouth, teeth and treatment of fever, sore throat and gum infections. [1] In addition to these health effects, it has been used as an aphrodisiac and sexual tonic. [1]
It seems Nkotaiat Acmella flowers that have properties against malaria and antilarvicidal, [4] [5] appears again, tea (hot water extract). [6]
Nucific Bio X4 Installation
(2E, 6Z, 8E) -N- Aasubotil-2,6,8- decatrienamide (aka. Spilanthol) [2] (about 0.20% w / w) [5] [1] with the study to 0.07% search [ 7]
(2E, 4E, 8Z, 10Z) -N- Aasubotil- dodeca-2,4,8,10-tetraenamide, the most prominent in the 0.71% [1]
(2E, 7Z) -N- Aasubotil-2,7- tridecadiene-10,12-diynamide (0.12%), (2Z) -N-phenethyl-2-nonene-6,8-diynamide (0.11%), (2E , 4Z) -N- Aasubotil-2,4- undecadiene-8,10-diynamide (0.25%), (2E, 7Z) -N- Aasubotil-2,7- decadienamide (0.04%), (2E, 6Z, 8E ) -N- (2-methylbutyl) -2,6,8-decatrienamide (0.07%) [1] (z) Non-2-en-6,8- diynoic isobutylamide acid (0.01%), (2E) - N -isobutylundeca-2- ene-8,10- diynamide (0.01%), and Spilanthic 2-methylbutylamide (0.04%) [7]
(7Z, 9E) -2-oxo undeca-7,9-dienyl, 3-methylbut-2-enoate (aka. Acmellonate) less than 100 ppm (1 mg / kg or less) [3]
And many other compounds will be:
triterpenoids of the 3-acetylaleuritolic [8] acid
And scopoletin [8] coumarin
VANILLIC acid, across Alwerleik acids across isoferulic [8] for being the last biologically active bugs repellent station [8]
It seems that the active compounds biologically to be N-akylamide, which have been implicated in improving sexual life through Maca (Macamide [9]) and pyrethrum (pellitorine [10]); this is different from most exciting vehicles aphrodisiac that works through terpenoids or saponins. N-akylamide category tends to be extracted into ethyl acetate: butanol extracted because of the relatively high polar [7] spilanthol can focus on the extraction of ethanol, which once found to contain 9.04% of the total N -Akylamides still 88.84. Spilanthol%. [Eleven]
Still being biologically active judiciary in Nkotaiat flowers, but it seems to belong to a class of molecules N-Akylamide Spinathol seems to be biologically active biologically active currently seen as the "primary"
2. Pharmacy
21. enzyme reactions
Nkotaiat flowers Acmella can inhibit the enzyme CYP2E1, also proved 0.067mM of spilanthol to prevent 55% and 75% of CYP2E1 activity in human liver microsomes, and expressed enzymes 2E1, respectively. [12]
3. Neuroscience
3.1. Pain
Has been investigated for its effects Nkotaiat flowers for pain relief was noted that the power consumption of the leaves numbs the tongue. [13] is the absorption of the active spilanthol biologically as well as through the skin, [14] when applied intracutaneously, 10% and 20% Nkotaiat flowers Acmella produced 70.36% and 87.02% of anesthesia during 5 minutes, compared with 2% Xylocaine active control (who produced Anesthesia 97.22% in 2 minutes) Nkotaiat flowers come. [13]
Other potential bioactive include Acmellonate, which proved the weakness of isolation numbing effect on the tongue. [3]
Possible pain killing effects when applied topically, it seems numbs the tongue at the same grass eaten as a salad
4. Cardiovascular Health
4.1. Triglyceride absorption
The time has turned out Acmella Nkotaiat flowers to curb pancreatic lipase activity when he was preventing the ethanol extract of the flowers used, and pancreatic lipase by 40% in the laboratory in the 2 mg / ml Nkotaiat flowers. [15] compared to the ES significantly Aframomum meleguetta (90% inhibition), also known as the alligator pepper, where up to 0.75 mg / ml inhibits pancreatic lipase from Nkotaiat flowers. [fifteen]
4.2. Blood flow
Nkotaiat Acmella flowers seem to rely lining characteristics vasorelaxing, with a portion of ethyl acetate and the presence of EC 50 value of 76.1ng / ml. We have already shown [16] This is an excerpt to have the content of scopoletin, which is both an antioxidant and vasorelaxant [17] This active Nkotaiat flowers may be the primary relaxation of vascular biology.
Bio X4 Inflammation and Immunology
5.1. Mechanisms
Excerpts hexane, chloroform Nkotaiat flowers appear Acmella to suppress the production of nitric oxide in macrophages stimulated with 80 ug / ml for 72% and 85%, respectively, they were isolated and seems spilanthol dose-dependent activation avoid macrophages (according to the evaluation of nitric oxide and conformation after stimulation with LPS) with 90uM reduce the production of nitric oxide 360uM 60% and about 20% of the production. It was accompanied by [18] This inhibitory properties by less iNOS and COX2 mRNA and protein, unless macrophages produce cytokines, and less activation of NF- kB in the nucleus (90uM and 180 uM activation to reduce the 57% and 38% of control). They believe that everything comes second general anti-oxidant properties. [18]
And the effects of unexplored potential, but anti-inflammatory in animal models
6. sexual interactions
6.1. Male Nationality
Nkotaiat flowers Acmella aphrodisiac gives the male rats in a dose dependent improvement of Mount latency, frequency, latency for a frequency, and improvements in the frequency of ejaculation and reduces after ejaculation (forgiveness) interval. [1] Although he quantitative flour for these improvements is not given, it is estimated derived from schemes that after 28 days of 150 mg / kg, and the improvements reductions in arc latency (51%), cumin and access (47%) latency after ejaculation ( 48%) and increasing the frequency of assembly (110%), and the frequency of intervention (the number of entries in the female within 30 minutes of observation; 350% gain, 2-9), and ejaculation frequency (the number of ejaculation in 30 minutes 66% improvement). These benefits were more important after 28 days supplementation compared with 14 days, which suggests the existence of the influence of accumulation. [1]
With regard to the pro-erectile properties (PEI) Viagra (5 mg / kg) study observed that the 293% increase in penile erection rate increase of 202% with flowers Nkotaiat Acmella [1] It seems even exist until two weeks after stopping the supplement. Which refers to the removal of long-active compounds rates, when measured 14 days after cessation of natural Viagra group and the highest dose of 150 mg has remained / kg Nkotaiat flowers 177% above baseline. [1] These effects were dose-dependent in nature, accumulated over 28 days (more power in day 28 of supplementation relative to Day 14), and then in vitro cell assay DS-1 was observed to increase nitric oxide 52% strong such as Viagra at the same dose. [1]
It seems beneficial effect all the parameters of sexual activity for males in the other row of Viagra for erectile pro properties, which exceeded Viagra. Preliminary evidence suggests that it is very powerful
7. interaction with hormones
7.1. Testosterone
With checks at 1.73 ± 0.11 ng / ml of testosterone supplements, testosterone levels increased by 20% .68% and 115% in the 50 mg / kg of body weight and 100 mg / kg and 150 mg / kg, respectively, after 28 days of supplements. [1]
At least one study suggests that increases testosterone after supplementation
7.2. Follicle stimulating hormone
Controls 1.41 ± 0.09 mIU / ml FSH (FSH) FSH increase of 23% .79% and 120% at a dose of 50 mg / kg of body weight and 100 mg / kg and 150 mg / kg ethanol extract respectively . [1]
7.3. Hormone
Controls 4.63 ± 0.11 mIU / mL hormone (LH) by 5% .13%, and 48% to 50 consumption, 100, or 150 mg / kg of extract ethnaolic Acmella Spilanthese TH. [1]
8. interactions bodies
8.1. Bladder
May be described Nkotaiat flowers Acmella that its generating properties for Paul in Sri Lanka Medicine, [19] and when the flowers test at oral doses of 500.1000 or 1500 mg / kg in rats at 13 mg / kg of furosemide as an active control dose higher Nkotaiat of flowers Acmella resulting in the production of urine within 1 hour after eating with similar furosemide (523% compared with 405% with furosemide) power still faces power more than 5 hours, with the passage of time furosemide exceeded the total production of urine. [19] This diuretic effect of dose was accompanied by the highest increase in urinary sodium (51%) and potassium (213%), despite the fact that the relationship if they did not change significantly, and the decline in pH urinary does not changes in protein, glucoseurea, or urine color. [19]
It seems that the diuretic is very strong when the flowers are consumed in high doses, the most powerful of furosemide in study
9. Safety and Toxicology
In rat studies using doses up to 150 mg / kg of body weight, it was not referring to hinderances toxic effects or function with ethanol extract more than 28 days of supplementation. It failed [1] 10 times this medicine (1500 mg / kg) ethanol extract of flowering tops with similar biologically active practice of acute toxicity in mice when administered in a single dose.
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