The recommended dose, active and quantities, and other details

Nucific Bio X4 -4 in 1 Probiotic

Taking (the recommended dose, active and quantities, and other details)
Typically, the use of a dose of 1-3g preventive treatment for nausea. This applies to morning sickness during pregnancy, motion sickness, and sometimes nausea caused by chemotherapy or process.

For other uses of ginger, 1 gram is usually used. It seems to be effective in increasing intestinal motility, but not enough to reduce the level of sugar in the blood in one study to try.

To increase testosterone, and perhaps advised Annex. The dose used in mice, after conversion to humans on the basis of body surface area, the equivalent of about 14G from natural sources (usually less than the percentage that can extract supplements).

Ginger can be ingested through several methods, the following approximate unification of 1 gram of ginger table: [57]

Capsule presence ginger extract the 1G
A teaspoon of grated fresh rhizome (the vertical side of the ginger root)
Two emitters (2 ml) of liquid extract
2 tsp (10 mL) syrup
4 cups (8 ounces each) of ginger tea, soak 1/2 teaspoon grated ginger for 5-10 minutes
8 ounce glass of ginger beer, made from real ginger,
2 pieces of crystallized ginger, each 1 inch square, 1/4 inch thick
Ginger is the common roots of Zingiber officinale Roscoe name, a plant that has a historical precedence medicine and spices and is one of the most widely used spice in the world. [3] uses the historical ginger include headaches and migraines, blood pressure and flow, and the common cold.

The most common is consuming ginger rhizome, or the vertical part of the root.


1.2. Installation

Ginger root contains 14 active major biologically are:

6-ginger (long name 1- (4'-hydroxy-3'- methoxyphenyl) -5-hydroxy-3- decanone), seen as the main biologically active below. [4] 6-ginger is not the only molecule in this category such as ginger 6-8 to 10-ginger ginger are also present in ginger. [5]
Methoxy-10-ginger [5]
1.7-International Settlements (4'-hydroxy-3 'methoxyphenyl) -5-methoxyhepthan-3- one [5]
10-gingerdione O1-deoxy-10- gingerdione [5]
hexahydrocurcumin and tetrahydrocurcumin [5]
6-and 10 shogaol shogaol [5]
6-paradol [5]
Gingerenone A [5]
Galanal A and B. [6]
Other compounds, found in many plants, are also found in ginger root:

Quercetin, 1.29 mg / g dry weight in the leaves for [7]
Kaempferol, a lower dose of 0.068mg / g dry rhizome weight [7]
Two of green tea catechins, catechin and Abakatchen to 0.19 and 0.56 mg / g dry weight paper, respectively [7]
Routine, about 0.2 mg / g of the leaves and 0.4 mg / g dry weight of rhizome [7]
Naringenin, and usually about 0.04 mg / g of the leaves and 0.02 mg / g dry weight rhizome [7]
Curcumin, which contributes to the nest color yellow rhizome [6]
The total phenolic content of ginger was both estimated at 157 mg / 100G fresh rhizome weight and 291 mg / 100 g fresh weight of the leaves. [7] The content of the total flavonoids seems 5.54-11.4mg / g dry weight, which is above the garlic, onion, papaya, black tea and semambu leaves everything at least twice. [7] It seems flavonoid content of the leaves to go to the rhizome during aging, with older plants find nutrients to the rhizome. [7]

From the above 0.6-ginger it seems to be present in higher amounts of ginger [8] Although the specific differences in the levels of these molecules on the basis of preparation, ginger source, and freshness. [9]

Nucific Bio X4. Ginger

Ginger is the primary ingredient in spicy ginger, and ketone body structurally similar to raspberry ketone and headlamp.





2. Pharmacy

21. metabolism

We found 6 ginger partially subject to glucuronidation with UGT1A1, 2B7 and 1 A3 enzymes mediate conversion of phenol derivatives as UGT1A9-mediated conversion to alcohol derivatives [10] -gingerol |. He published November 15 = 2006 | Author = E1 Pfeiffer, Heuschmid FF, Crans S, M Metzler | journal = J agricultural food science]



3. Neuroscience

3.1. Nervous hormone serotonin

When considering the serotonin receptors, it seems that many of the compounds in ginger have affinity for-HT2B 5 including 8-shogaol (Ki's 1.8 μM), 10-ginger (4.2μM), 10-Dehydrogingerdion (7.6μM) 10-gingerdione (12.5μM), and 8 Ginger (25.4μM). [Eleven]

There seems to be nearly twice (greater than 10 microns) L5- most HT2C receptors except for phenol ginger 8 shogaol, which has so than 3.8μM. [Eleven]

Ginger basic phenolic compounds failed to show affinity for 5-HT6 receptors in the laboratory. [Eleven]


3.2. Appetite

2 grams ginger, if taken with a meal, can reduce a little, but too much hunger and calories later (no effect on satiety). [12]


3.3. Knowledge

And has been associated with oral doses of ginger extract 400-800mg (7.3% 6-ginger, 1.34% 6-shogaol) healthy women (age 54 +/- 3.57) for two months with increaes of N100 amplitude and amplitude P300 (raised the prospect) and 800 mg each dose , Consecutive. [13] Note that this study also, more practical, and showed improvements (speed and accuracy) in word recognition and the working memory tests (spatial and digital), as well as improve the response time of the act of choice. [13]

In mice exposed to the right clogging East cerebral artery (MCAO) Ginger 100, 200 and 300 mg / kg, indicating that the ginger in all doses was able to improve the rate of improvement in spatial memory after a blockage for 7 days, and improve up to 21 days. [14] This study also used as an active control piracetam 250 mg / kg, piracetam and faster to restore spatial memory after a blockage, not drug retention time influenced tested. The piracetam so the two less than the effective doses of ginger increase in neuronal density of the hippocampus after 21 days, but in a lesser degree of drug Arespt (other positive anti-drug). [14] With respect to the volume of cerebral infarction after occlusion, / kg and 200 mg of ginger is more effective than all the positive controls to reduce the size of infarction after occlusion although not much better to maintain the self-enzymes anti-oxidant levels. [14]



4. interact with the glucose metabolism

4.1. Blood Glucose

Ginger, through her work as a discount of serotonin receptors, can increase insulin secretion from INS-1 cells, a cell line of research to the beta cells in the pancreas. [15] serotonin usually suppresses the secretion of insulin in these cells, and can antagonize the 5-HT (3) receptor alleviate this repression and lead to low blood sugar. It may be reduced up to 35% in mice [15] and shows some effects on Type I diabetic rats as well, although the beta cells less. [16] (1) grams of ginger root, taken orally in healthy humans, and it seems to be effective in significantly reducing blood sugar (show any significant trends), but it can alleviate some of the effects of sugar in the blood, as reduced movement in the stomach. [17]

Bio X4

 Obesity and fat mass

5.1. The thermal effect of food

At least one study has indicated that ginger, when taken in conjunction with 2G (especially carbohydrates) from the food, and they are able to spend more calories during the next 6 hours after that meal. It was associated [12] 2G ginger consumption at a rate of 43 +/- 21kcal increase in metabolic rate in a sample of 10 men, and with respect to any ginger. [12] In general, independent metabolic rate was not affected.

You can increase the thermal effect of food, and increase metabolic rate (a bit; 43 +/- 21 calories) in the context of a big meal


6. interaction with digestion and nausea

6.1. Nausea

Traditionally ginger for nausea and dizziness have recommended seems to be more effective in suppressing the seasickness of dimenhydrinate (Gravol). [18] [19]

It seems to exert these effects instead of neurally gastrically, [20] and can accelerate the process of digestion in the stomach, although the increase in traffic is not the mechanism by which relieves nausea. [21] [22]

Because of interactions with the digestive system, many of the side intake of nausea effects produced here. Complications are usually mild digestive tract after ingestion. [2. 3]


6.2. Motility

Ingestion of ginger may have the ability to accelerate gastric (stomach) transit of food. The biggest benefit in countries that suppress gastric motility usually appears, and during illness (nausea) [24], high blood sugar [17] or a case of illness. [25] [26] and can occur in healthy people by stimulating antral contractions, but because it is less effective than bridges statistically significant, with some positive [27] [22] and negative [21] results. The effects of ginger gastric motility appear to be independent of meal. [27]


63. Stomach

A study on ginger and its impact on the lower esophageal sphincter (LES), which 1G of ginger able to reduce LES pressure, which can exacerbate the negative impact of heartburn in people prone to infection. [28]

Bio X4 Puff

Ginger is known to have an impact, "carminative, a break and the expulsion of intestinal gas. Traditionally used to treat flatulence and gases. [28]

It may be due to a decrease less esophageal sphincter above the stomach, which can cause the gas produced in the stomach to leave rather than orally through the rectum this effect. [28]



7. Use in pregnancy

7.1. morning sickness

Its effects on morning sickness, a dose of 1 g, and parallel to those mg vitamin B6 75 [29] [30] or a little more effective. Study [31] and at least one that increased doses of ginger to 1,950mg and found that it was more effective than 75 mg of vitamin B6, however. [32] Ginger is almost as effective as metoclopramide (drugs), but a little less effective. [33] compared with dimenhydrinate, ginger seems to have lost time to the effectiveness of (dimenhydrinate which is the most effective for the first two days, then small differences), while sleepiness associated with dimenhydrinate. [3. 4]

Find nausea generally very reliable can be extrapolated to relieve nausea associated with pregnancy, and it seems that ginger to be effective. Whether or not safe for pregnancy, short-term (4 weeks or less) and used it seems to be free of side effects with the use of clear and unknown

7.2. Dysmenorrhoea

Ginger has twice been proven to reduce the pain associated with periods in women at a dose of 1 gram per day, on both occasions when taken to four divided doses of 250 mg. [35] [36] is as effective as ibuprofen and mefenamic acid in this regard [36].

A- placebo-controlled two months between high school students and not on birth control with dysmennorrhea primary trial suffered from a decrease in pain as measured by the visual analog scale of 22% in the first month and 61% for the second month in a row in the use of ginger. The [37] and 250 mg dose of ginger powder three times a day for four days, starting the day before the start of Menstural bleeding. [37]



8. interact with hormones

8.1. Testosterone

Aqueous extract of ginger has been found (600 mg / kg of body weight) to increase testosterone in the blood, and testicular weight and the content of cholesterol in healthy mice testis. [38] In another study using doses of 500 mg / kg / kg of body weight 1G dose-dependent increases found in semen quality, which depends on an increase in the dose of testosterone, all 0.3nmol / L basically 0.6nmol / L approach after 14 days with a minimal differences between the 14 and 28-year-old has been reported [39] increase testosterone effects in low-rats up to 100 mg / kg of body weight (extract powder) with observation 1.60 ± 0.091ng / ml to 3.71 ± 0.387ng / ml to 100 mg / kg per day. [40] There was no increase in testosterone in the 50 mg / kg per day in this study, but did not reach statistical significance. [40]

Despite the increase in testicular volume after 14 and 28 days supplementation, and this may be due to inflation in the epididymis. The prostate and seminal bags unchanged. [41] After the tube feeding 2000 mg / kg daily for 35 days (high dose) there seems to be a reduction in testis size and weight. [42] raised suppose that this book be due to the reaction of adverse reactions from androgenic activity. [42]

Ginger has been implicated in preventing downstream signaling involves testosterone enlarged prostate, as we have seen in LNCaP cells, which reduces the secretion of ginger custody of prostate specific antigen induced by testosterone (up to 21%). [43] Ginger also due to apoptosis in these cells, and were capable of reducing BPH linked of testosterone in experimental animals. [43]

In studies of the reproductive system damage occur, and shows the effectiveness of ginger in the prevention of oxidative damage caused by aluminum chloride [44] and to mitigate the decline in sexual activity associated with diabetes. [45] twice ginger has been implicated in reducing damage caused by testicular cisplatin. [46] [47]

Ginger mechanisms on the testosterone is not really known. According to previous messages (in response to the trials) may be through thromboxane inhbition [48] and the impact of the joint between the ginger and the reference drug cimetidine. However, cimetidine appears to be anti-androgen [49] (reverse ginger) and this mechanism working theory may not be legitimate.

Ginger seems to be effective in increasing testosterone levels in rodents
In a study of infertile men, I noticed improvement in fertiliy standards and semen was linked to three months of treatment with a 17.7% increase in testosterone levels. Ginger is not used to determine the dose. [50]

Preliminary evidence to support the use of ginger to increase testosterone levels, although this may appear only in men with infertility at this point in time

8.2. Estrogen

Study to assess a variety of medicinal plants of the characteristics of estrogen noticed that Ginger was able to activate the estrogen receptor in yeast assay with EC50 of 77.26ug / ml when the test was extracted ethanol 95%. Similar licorice Uralensis power. [51]



9. the body interactions Terminal Equipment

9.1. Testicles

Ginger supplements for men with infertility (3 months of treatment, and the dose is selected) appears able to increase sperm count (16.2%), mobility (47.3%), growth (40.7%), normal morphology (18.4%), and size (36.1% ) along with reductions in fat ejaculation peroxide as assessed by MDA (53.7%) and 26.7% increase glutathione). [50]



10. interactions elements nutritious food

Bio X4

. 5-HTP

5-HTP is the precursor amino acids of serotonin, a neurotransmitter commonly associated with happiness and joy.

Ginger his action as a serotonin receptor antagonist, which many found in the intestine. These effects appear to be mediated through gingerols and their metabolites. [52]

Ginger has been shown that oral treatment (such as juice) in mice to prevent serotonin-induced high blood sugar that. [16] This usually occurs as the excess blood sugar serotonin suppresses the secretion of insulin, and the inhibition of this reaction causes a relative decrease in the level of sugar in the blood.

Serum as gingerols in the brain seems to be ten times less than the level in the intestines and stomach after eating, [53] it seems that in practice, and this hostility can only be related to serotonin digestive and systemic reactions.

This could be the face of any act of serotonin in the gut and precursors, and therefore the combination is not recommended. You can not interact negatively with the actions of serotonin nerve because of the very low dose used.

10.2. Magnolia officinalis

Magnolia or Magnolia officinalis bark is a herbal product that two active "Magnolol" components and "Honokiol" reduce naturally; its effects in the fight against depression (20 mg / kg of body weight together) which enhances the synergy when coingested with ginger 14 mg / kg Ginger body weight in mice despite the absence of anti-depressant effects in isolation. [54]



11. The safety and toxicity

11.1. Public

In this analysis, "and the comments made on this subject, and show side effects observed in clinical trials to be associated with discomfort and the grave never gastrointesinal. [55] [56] [57] and these occur irregularly in the recommended dosage 2.1 g scale to prevent nausea.

Studies show on mice that when fed oral (gavage) any significant changes to negative in blood chemistry or weight of the device to 2,000 mg / kg of body weight for 35 days, except for low volume potential testicles, because of reactions activity androgenic negative response . [42] This dose is 320 mg / kg of body weight per day when humans turn is based on the body surface.

The low doses tested (500 mg / kg) for up to 13 weeks in rats of both sexes, with notice any side effects. [58]


11.2. Carry

He noted meta-analysis of randomized trials in June that were no reports of adverse effects associated with ginger in six selected studies in connection with pregnancy. [59] another review [57] investigated specifically four trials [60] [61] [62] [29] and found no adverse effects at a dose of 1 g ginger extract.


11.3. Interactions

It should not be combined with the anti-clotting effect of ginger with pharmaceutical drugs (prescription), with the same effect of warfarin, and possibly analgesics such as aspirin. Doubly important when used during pregnancy. [63]