The common nettle, stinging nettle, Ortica, Tsuknida

What You Should Know
Also known as

Nucific Bio X4

Urtica dioica, Radix Urticae, the common nettle, stinging nettle, Ortica, Tsuknida


Things to consider

I decided some experiments to just throw in multiple herbs, so that can not be attributed to the benefits seen Urtica dioica isolation from these studies
Apparently, may swish dioica nettle leaves for joint pain (although dietary supplements are the roots, due to the higher levels of the active ingredients) helps joint pain
Taking (the recommended dose, active and quantities, and other details)
120 mg Nettle (root) taken three times daily (360 mg total) is associated with a profit of benign prostatic hyperplasia.

Allergies, the studied dose of 300 mg twice a day of freeze-dried nettle leaves.

Is much evidence for nettle root and expand the prostate best of nettle leaves and allergies.
Nettle, Urtica dioica aka family urticaceae, is the herbal comprehensive often used for "Men's Health"; and usually refers to the prostate and urinary tract is initially citizens of Africa and parts of Asia, and now it is found in all temperate zones in all continents. [5] In some cases it has been used to promote hair growth and the promotion of breastfeeding and prevent uterine bleeding after childbirth.


1.2. Installation

As an herbal supplement, nettle contains a variety of nutrients. These include:

Vehicles beta-sitosterol glucoside and campesterol daucosterol and related [6]
Scopoletin [6]
Stigmasterol
Peel such as (+) -. Neoolivil, isolariciresinol and pinoresinol [7]
Secoisolariciresinol intestine and the main metabolite, enterofuran 3,4-divanillyltetrahydrofuran and [7], the latter which seems to have a high affinity for binding to SHBG [8]
Ursolic acid [9] The
14-Ooctakozanol [9]
Oolaanolik acid [9]
The lectin is rooted affinity with moeities for N-acetylglucosamine [10]
Fatty acids of oleic, gadoleic, greasy, Albalmtewolak and erucic acid [11]
Quercetin, kaempferol glycosides and isorhamnetin and some (most rutinoside and isorhamnetin-3-O-neohesperidoside) [12]
Coumaric, which in coumaric acid is 5 micrograms / g [12] [13]
Chlorogenic acid and caffeic acid (a metabolite of chlorogenic acid) [12]
RR VANILLIC structurally related compounds (homovanillyl alcohol 8mcg / g, acid hydroxycinnamic, 20mcg Alwerleik / g) acid [14] [13] [15]
Some anthocyanins, particularly pelargonidin [16]
Vitamin C (ascorbic acid) to 130 mg per kg new station [12]
A serotonin, acetylcholine and histamine content in the hair; [12] and this can contribute to a sense of cleaning / burning plant experienced a touch of fresh nettles [17]
The active ingredient tends to be regarded as beta-sitosterol. A molecule daucosterol daucosterol after separated from the rest of glucose. There is some confusion about whether or not it is really active molecule, the total quantities of beta-sitosterol tend to be less than 0.01% if not otherwise concentrated and isolated beta-sitosterol seems when dealing with higher than 60 mg doses (the most common prostate Health nettle use) effect. [18]

Bio X4 interact with hormones

21. testosterone

In a study of 558 patients with benign prostatic hyperplasia, it was measured testosterone levels, and the lack of statistically significant differences between the control and experimental groups to 120 mg taken three times a day was found. [19]

A study conducted on mice increase in testosterone in the blood is associated with nettle, but it was all experimental groups also testosterone supplements. Have been found [6] nettle to continue to raise circulating levels of testosterone, however, through the inhibition of reductase A5. [6] However, stinging nettle root plant also has a hormone inhibitors can contribute to this effect. [9]

Moreover, you can peel nettle interfere with sex hormone binding globulin (SHBG) and to prevent associated with androgen and estrogen. The bottom water alcoholic 10% may reduce the link DHT SHBG for up to 67%, and the effects are slightly less excerpts from the water. [20] [21] and the inhibition appears to be dose dependent in the laboratory. [22] husks isolated retain this power, and even the displacement of DHT inhibition of SHBG by 60% (secoisolariciresinol), 73% (enterofuran) and 95%. ((-) - 3,4-divanillyltetrahydrofuran) [5]

Nettle can increase reasonably testosterone, but conducted the study mice have not been the answer to this question, and turned negative human study. At this point in time, there's no strong evidence to suggest nettle may increase testosterone levels


3. Interaction with health device

3.1. Prostate

A large clinical trial of 558 patients showed that the nettle is able to reduce urinary complications (low flow) associated with benign prostatic hyperplasia to 120 mg three times daily rate. Was [19] Nettle also able to reduce the size of the prostate still have no effect (beneficial or negative) in circulating testosterone levels. Results similar to those found in other interventions, though confused with other nutrients such as fruits SABAL [3] [1] [2] or creeping repens. [4] Studies that follow the use of the post-trial period, and long-term benefits without an increase in side effects. [19] [23], at least in mice, this rate decreased dilution of urine also seen with the main ingredient isolated, beta-sitosterol. [6]

These effects resulting from the extraction of nettle have the ability to work, such as an inhibitor of 5 A- reductase, preventing the conversion of testosterone to dihydrotestosterone (DHT), with IC50 ranging from 0.12-0.32mg in the laboratory based on the extraction method (with oil and ethanol may be extracts having more Authority); about ten times less active than finasteride. [6] by inhibiting the conversion of testosterone to DHT prostate, and can reduce the size of the prostate. [24]

Isolated beta-sitosterol appears to be equally as strong as nettle when it rose to about 60 mg, and can be an effective element in the prostate. [6] The dose of beta-sitosterol in nettle, however, is less than that dose. Related compounds Campesterol, sigmasterol and stimast-4- en-3-one may also be active ingredients, through the inhibition of the sodium / potassium pump prostate. [25]



4. interact with inflammation

4.1. Mechanisms

Nettle seems to be able to do the role of cyclooxygenase inhibitor (1 and 2), and inhibition of prostaglandin D2 synthase hematopoietic. Three anti-inflammatory action. [26] IC50 value for the inhibition of COX 160 +/- 47ug / ml for COX-1 and 275 +/- 9ug / ml COX-2's. [26]


4.2. Topical

Several experiments have looked at human topical application nettle plant for its ability to reduce joint pain. Proposed exploratory study (not included), it is useful to Urtica dioica topical application papers [27] However, it was a double-blind, you go into the issue of mixed results. Urtica dioica leaf was applied to much better than placebo thumb [28], while its effect on pain in the knee is not better than placebo. [29] The best results with respect to papers found in topical cream industry with stinging nettle root, but only appeared in this one study. [30]

Bio X4 Oral administration in vivo

Study on osteoporosis investigation in oral ingestion of Nettle found no benefit, but mingled coingestion fish oil. [31]

Varying effects in terms of biomarkers of inflammation were seen. And one study found a decrease in IL-6 with oral administration in patients with type II diabetes [32] while another noted an increase in IL-6, when she was a low baseline levels to normal. [33] Moreover, the first study, no significant effect on TNF -a found [32] whereas the second Notice of change TNF- secretion in response to LPS and management. [33] It is reasonable nettle plant can be immune, but today this claim is not supported.

Has potential anti-inflammatory, but studies currently conducted in humans are medium and vary widely in the media also applied for comparison. There is a need for additional studies to earn some dose consistency.


5. Interaction with breast

5.1. Sensitivity Rhinitus

Nettle seems that the use of some of the community as an alternative to the "natural" sensitivity to clear the sinuses. [34] The use of this nettle therefore said to be free of side effects [35] and associated [36], depending on who you ask.

I found a double-blind study to investigate the effects of nettle sensitivity Rhinitus that 600 mg was able to reduce the side effects associated with sensitivity Rhinitus, and that 48% of people are considered better than other over-the-counter for free (not included). [37]

These effects appear to be mediated by anti-inflammatory pathways. In particular, the plant has turned out to be a nettle discount of histamine and inhibit mast cell tryptase. Two mechanisms work perceived as anti-allergic. The [26] values ​​IC50 251 +/- 13ug / ml (hostility) and 193 +/- 71ug / ml (negative transformational) for the histamine receptor and 172 +/- 28ug / ml for inhibition of mast cells. [26] Other inflammatory effects of nettle, as COX1 and COX2 inhibition may also contribute to the anti-inflammatory effects sinuses. [26]



6. Safety and Toxicology

6.1. Public

LD50 aqueos to extract the nettle, when injected, is 1.72 g / kg of body weight. To worsen to 1.93 g / kg when using the root extract. [5]

Oral administration for up to 1.31 g / kg in mice has been well tolerated. [5]


6.2. Sensitivity and irritation

Is folded nettle dioica "Nipper" papers because, well, itchy skin when touched. It leaves skin irritation seems mechanically [38] and the body responds to the factors that cause itching and dermatitis (skin rash) and urticaria (hives), moments after his release. Contains [39] papers are also various chemical irritants, such as 5-hydroxytryptamine, acetylcholine, histamine, formic acid, and leukotrienes. [40] [41]

For the most part, transient contact with nettle is harmless, although annoying.

Despite this irritation, it is popular for the treatment of pressure Urtica dioica leaves in pain in the joints to relieve pain. Three trials this form of administration has been studied with mixed results. [27] [29] [28] The topics tend to report on the application to be irritating, but not to the point that acts as a deterrent.