Jack is a walking stick grass name to the more commonly known as tongkat ali, ginseng Malaysia, or Longjack.
Nucific Bio X4
The effects of Eurycoma aphrodisiac very reliable sexual and seems to include a variety of animal models, limited evidence in female mice, but it seems to affect a similar extension as in men. It is difficult to make sexy comparative analysis of another aphrodisiac herbal to assess the strength, but anecdotally Eurycoma is one of the best.Besides aphrodisiac, and it can also increase Eurycoma animals produce sperm and can directly act as proerectile agent. One molecule at least in Eurycoma associated (9 hydroxycanthin-6- one) with each delay in ejaculation, as well as the pro-erectile properties (although this molecule's ability to work through a waste of extract of Eurycoma does not know).
Eurycoma hormonally seems to have a significant adverse effects of estrogen and tamoxifen in the laboratory has a similar strength when the active substance is injected. I found, but there are no studies in humans today promising studies or evaluate oral intake extract Eurycoma. On the side of things testosterone, literature looks promising unnecessarily. Defines peer-reviewed evidence does not currently Eurycoma tonic testosterone in healthy people or mice, but many are quick to cite studies offers from MI Tambi claims these increases in testosterone. Nothing seems Dr.Tambi research presented at the conference to be indexed in MEDLINE and can not be proven claims expressed.
What You Should Know
Also known as
Longjack, tongkat ali, ginseng Malaysia, longjax, Kay Ba Binh, Pasak Bumi, Langir fasting, Tung Sawa
Things to consider
A walking stick Jacques able to increase libido and sexual desire, but otherwise non-stimulatory
You can reduce anxiety, but I studied a little
Active ingredients gives the bitter taste
1. sources and structure
Eleven. Resources
As it is well known as a walking stick Jack tongkat ali, Longjack or Malaysian ginseng (although not in the same plant family Panax ginseng). Libidus belongs to a family of plants with Eurycoma being family Simaroubaceae. Four stations belong to this family; Apiculata, Harmandiana, longifolia and latifolia where only the use of other medical types. [1]
Other names given to this plant is Libidus Sawa Tong (Thailand), Pasak Bumi (Indonesia), Kay Ba Binh (Vietnam), and Langir Siam (Bahrain). [2] vividness may vary depending on the location of the cultivated grass, [3] it shows that normalization would be wise.
Bio X4 Installation
Libidus tends to contain:
Quassinoid compounds found in the plant family Simaroubaceae [4] [5] including vehicles Eurycomanone (usually an average of 1.6% of dry weight content) is seen as the main eurycomanol and biologically active. [6] At the present time, are known more than 150 quassinoids to exist between the four types of Eurycoma [3]
Eurycolactones [3]
Canthin-6- one [7] metabolism, such as 9-hydroxycanthin-6- one [8] and 9 methoxycanthin-6- one [9]
Eurylene and teurilene derived squalene. [10]
A compound known as 23,24,25-tirucallanoid trihydroxytirucall-7-EN-3,6- debt [11]
Eurypeptides and spare part consists of protein
Glycosaponins
Mostly about triterpenoids of the structures' quassinoids ", is the main one known eurycomanone. Bioactive Others include Canthin-6- category one and possibly eurypeptides citizenship; contribution from Other components are not known
1.3. Search or extracts patented
LJ100 is a proprietary blend of Libidus (with reference to the Longjack LJ) name, consisting of 22% and 40% eurypeptides glycosaponins. It is 100: 1 extract, so that the focus is biologically equivalent 1G to 100G Maxidus dry weight with respect to two of the elements mentioned above. Patent Details can be found here. [12]
Patented extraction populat's eurypeptides and glycosaponins
TAF 273 to extract uranium content quassinoids eurycomanone and has a 23.6% +/- 0.9, 6.4 +/- 0.1% 13α (21) Content -epoxyeurycomanone, +/- 0.8 13α 0.1%, and the content of 21 dihydroeurycomanone, and content eurycomanol and 4.8 +/- 0.2 %. [13]
TAF 273 content eurycomanone other relevant non-uranium particles
2. Pharmacy
After oral administration of 50 mg / kg in mice Eurycomanone through grab center, Cmax 0.33 +/- 0.03 and reached micrograms / ml TMAX and 4.40 +/- 0.98 an hour, that (as compared to injection) resulted in bioavailability by the mouth of 10.5%. [14]
/ Kg Eurycomanone size distribution was seen after injection of 10 mg 0.68 +/- 0.30 L / kg. [14]
Injection remove kinetic produced 0.88 +/- 0.19 H1 mean removal rate constant, half-life of 1.00 +/- 0.26 an hour, and the rate of removal of 0.39 +/- 0.08 L / h / kg. [14]
3. neuroscience and brain
3.1. Bah
Libidus appeared usually in Aphrodisias, because it is one of the traditional roles when used by humans. [1] It was reported that the glycoprotein content Eurycoma is responsible for the pro aphrodisiac (and contribute content eurypeptide partly by increasing testosterone) effects, but these claims and presentations of the conference and not in the magazines. Arise [15] These claims of the patent on LJ100, concentrated extract of proteins and sugars eurypeptides. [16]
Mechanisms is largely unknown, and may not be relied upon when the male
With regard to animal studies, one using 500 mg / kg each day Libidus males inactive rats sexually for 6-12 days fell noted latency ejaculation, but failed to find significant differences in Parliament, interference, or latency after ejaculation after the first dose, but Each of latency after ejaculation (24.1% decrease) and Cummins ejactulatory (45.2%) became more important when the treatment was extended for 6 days without more than 12 days to improve. Increased [17] The Assembly also frequency of 0% in the base (with no effect of a single dose) to 25% in 6 days and 37.5% in 12 days; and that these effects are believed to be mediated through increased testosterone levels. [17] This form through sexual contact mice inert has been used elsewhere in the 200-800 mg / kg of body weight for 10 days, but nevertheless showed promise great quality of this study is questionable because of Bah measure yawning used, see Authors that was reliable (and not biomarker typically used for Bah). [18]
The first study failed to find evidence of improvements in the selection of a partner, [17], and that are incompatible with previous studies conducted on mice. [19] [20] observed [21] authors that this may be due to the presence of various animals used model, [17] This study used mice inert through sexual intercourse during the previous sexual contact using naive 19] and experience mice [22] [23] noncopulators, [20] and mice in middle-aged normal through sexual contact. [24] [21] [25] [26] Perhaps the most interesting and its effects aphrodisiac in mice and castrated experience through sexual contact, where 200-800 mg / kg daily for 10 days increased all measurement parameters of sexual activity, but to a lesser degree than it was 15 mg / kg injection of testosterone. [27]
Improvement seems to be the most reliable in themselves around females site mice but there are other areas of possible inhalation anal (both indicators Bah) and increasing the frequency of assembly; decreased speed latency and low latency after ejaculation (the time between rounds) is less reliable but still significant improvements appear in These studies.
It seems to have aphrodisiac reliable in experimental animals and the effects of aphrodisiac does not seem to be confused with patent issues
When tested on humans, supplementation of 300 mg of extract of water per day for a period of 6-12 weeks is able to increase sexual desire in the range of 8.4 up to 10.8% (relative to baseline) through self-assessment survey report. [28]
Bio X4. Anxiety and Stress
In addition to high test maze in the open and various juices of a walking stick injection 0.3 g / kg before the test showed improvements in all parameters measuring anxiety (fecal pellets, and inertia (s), cross the square as well as a maze high) with a drop from 31.2 to 36, 3% wrest control used according to the deadlock. This was slightly less effective than the active diazepam 1 mg / kg of control, and the reduction of inertia to 25.9%. [29]
The mice also fungal and those with more than 5 episodes of fighting has also been tested in the shock caused by the fighting rings Libidus foot test decreased 18.0 +/- 0.4 5.3 6.2 episodes wrestling control of the fight; again a little weaker than diazepam (3.5 +/- 0.2). [29]
Only one study today, but it turns out anxiolytic properties. It may help Bah likely by reducing the possibility of not being able to psychological dysfunction
In humans confirmed eurycoma supplements otherwise a day for four weeks and is associated with increased tension in accordance with the evaluation of the survey self-determination. [30]
4. sexual and sexual organs
4.1. Erectile function
Any group or in the secondary with sexy aphrodisiac properties of Libidus can, and increase the frequency or pressure leads to an erection. Study on mice of different extracts of Eurycoma test in 200 400, or 800 mg for 10 days in castrated rats (to control to some extent the effect of testosterone) All excerpts test (water, butanol, methanol, chloroform) were equally effective in increasing the frequency of erectile dysfunction, with a nonsignificant trend for dose response. [31] a subsequent study using the same dose of four excerpts measurement caused by each of testosterone and castrated mice 12 weeks indicated that there is no testosterone muscle in castrated rats Ani leavator pelvis increase in size with all excerpts from a 13.2 to 23.4% , which shows the effect of androgenic. [32]
Libidus (isolate more specific -6-one 9-hydroxycanthin) seems to be a candidate biologically active compound. [8] in the laboratory, and it was 9-hydroxycanthin-6- one capable of carrying relax ephineprine strips cavernous contract with the EC50 of 6,7 +/- 0.9uM, and increasing the elimination of endothelial EC50 7.5 + / - 1.1uM. [8] There seems to be mediated by nitric oxide (as incubation with L-NAME did not cancel effects), or alpha-adrenergic as yohimbine, but it seems to prevent the release of CA2 +, which would lead to the penis shrinkage (one as a result of combat erectile dysfunction). In vivo tests in rabbits he indicated that the direct injection of up to 0.2 mg of this compound to increase the pressure intracavernosus injection in mice 1 mg / kg was as strong as clomipramine in delay ejaculation, according to assess the pressure seminal vesicle. [8]
Pro-erection and may be able to delay ejaculation (you need the latter claim more studieson)
4.2. Semen Parameters
The possible mechanism of action of Libidus to increase sperm count and increase the number of Alntafa cells through suppression of acts of estrogen, and this does not apply to sperm motility, which seems to be mediated by other mechanisms; sperm size without investigation. [33] Eurycomanone in the testes of mice after chronic eating, which proves that you can get to this place, and indicates that it may follow the cumulative effect. [3. 4]
In the laboratory, Eurycoma in 2.5ug / ml (based on 200 mg orally administrationed used in human intervention [15] and on the assumption 80KG male human) failed to find any effect on sperm vitality, and oxidation (through ROS) or reactions particle Terminal and no results have been observed up to 20 micrograms / ml. [35]
Also has the ability to increase the viscosity of sperm in healthy subjects receiving 200 mg of Libidus, and can increase the amount of sperm is classified as a "sterility" is sufficient to vaccinate [15] This study used 200 mg found increases sperm concentration. 65.5% in 9 months time (with low increase in measuring 3 and 6) rate, while the 19.3% increase in the volume of non-observance of sperm to reach statistical significance. 9 months time, about twice the normal sperm morphology offered (5.28 +/- 0.66 to 10.29 +/- basis 2.52 9 months, with benefits seen a similar force in 6 months). [15] a similar increase in the volume of semen seen in pigs in a short period of time, but this study was wrong Tribulus terrestris and carthamoides Leuzea. [36]
You can increase sperm count and size, and the results were mixed on changes focus because the first sound. Apparently fertility in men favor
5. Exercise reactions performance
5.1. Speeches
A pilot study with Libidus using the circuit 14 men training every day (60% of 1RM for 2 sets of 10 repetitions, during 10 seasons with rest periods of 1 minute) using 100 mg of extract said Libidus Group experienced a treatment increase in lean body mass in 5 weeks (52.26 +/- 7.18 until 54.39 +/- 7.43 kg; 4% increase), while the placebo saw not have seen [37] Both teams increase lean mass increases in strength with Eurycoma. Group gained much greater than the force, and a decrease in fat mass was observed in both groups did not differ significantly. [37]
Experimental study presented at the conference Eurycoma with promising performance in weightlifting in healthy men, have not been replicated
Other studies using a product called Agromás, a solution containing water-soluble extract of a walking stick 0.1 mg / 100 ml and cassia cinnamon confused with the 2 mg / 100 ml was conducted. Electrolytes containing calcium, sodium, potassium, phosphate, administered in 3 ml / kg every 20 minutes for the test and an average of about 0.67mg Eurycoma by topic. [38] Studies using this note who drink while cycling resistance were higher by 3.4% with herbal drinks are not statistically significant. [38] due to the quantity of the poor ingested, has another study, where 12 players gave them 150mg Eurycoma daily for 7 days and then again earlier when an article (60 minutes a vicious loop playback in VO2 60% maximum, followed by a trial time of 20 minutes on a bike ERG) on the eighth day, and this study found no improvement in the management of the economy, and public performance or physiological responses such as temperature, heart rate, blood sugar or fat. [39]
Significnat benefit to exercise the heart and blood vessels did not show
6. skeletal bone health
6.1. Osteoarthritis, which rely on the androgen
Osteoporosis is secondary to androgen deficiency (seen in older men sometimes) is a form of osteoporosis in men who have a higher mortality rate than women [40] in about 31% of the appreciation. Made [41] and there are a few studies to evaluate the interactions of Eurycoma with skeletal bone mass.
A comparative study between the standard testosterone replacement therapy to 8 mg / kg daily injections against half the dose of testosterone along with Eurycoma low dose (15 mg / kg, 1.6% eurycomanone) in neutered older mice (research model for androgen deficiency [42]) that more than six weeks after the Department of 4 mg / kg of testosterone along with 15 mg / kg Libidus did not behave differently 8 mg / kg of testosterone. It could indicate that Eurycoma be an effective complement to reduce the required doses of testosterone therapy. [2]
Bio X4. interaction with hormones
7.1. Testosterone
Currently Libidus promotion mechanism to increase testosterone levels to content eurypeptide, who claimed that increasing the activity of CYP17 (17 α-hyroxylase / 17,20 lyase) enzyme in the testes, which increases the rate pregnenoline in the diversion of precursors and subsequent androgen dehydroepiandrosterone. These claims go back to university thesis by Ali and Saad (1993) entitled "biochemical effect of a walking stick Jack in behavior, fertility, and sexual sex hormone and analyzed" in the University of Malaya, this thesis is not available online.
Currently not supported by the literature, and the inclusion of all mechanisms in patents
In normal mice otherwise, 15 mg / kg failed to grab the center Eurycoma (22% eurypeptides, eurycomanone 1.6%) to increase testosterone over a period of 6 weeks. This dose is equivalent to oral doses of 100 mg in humans, according to the authors. [43] The only other study in healthy male rats noncastrated use much higher doses of 200-800 mg / kg and found an increase in muscle size leavator anal, suggesting the existence of the influence of the pro-androgenic. This study measuring testosterone levels in the blood. [32]
Animals in hypogonadal or non sexually active, 500 mg / kg seemed a walking stick to increase testosterone in the blood of more than 50% (a little less than 2 ng / ml for more than 3 ng / ml, and the data derived from the chart). When measured 12 days after ingestion [17]
The study showed that the mice were castrated any improvement in testosterone levels, but use less of the above studies indicate an improvement of testosterone in hypogonadal mice dose. [43]
Tests on mice suggest that increased testosterone levels during periods of low testosterone (hypogonadism) in mice or clinical signs of hypogonadism show (not sexually active), and there is a shortage in the conclusions that can be done in the proper mice
In individuals with hypogonadism late from the beginning, Longfolia (dosed as water-soluble extract 200 mg) it is effective in improving libido and testosterone levels in the blood. Ran [44] This study four years in hypogonadism clinical in Malaysia and evaluated 320 men with testosterone in the blood less than 6umol / L (hypogonadism clinical), and observed for a period of one month increase in the average testosterone levels of 1.51umol +/- 5.66 / L to 8.31 +/- 2.47umol / L, an increase of 46%. The use of any placebo in this study. [44]
Some studies [45] [46] Some cite up to 4 units by the author in various conferences MI Tambi can not be accessed via the Internet. Tambi MI not grab a patent used (LJ100) [12] and a separate trial in healthy men were able later to find an increase in testosterone. [28]
Evidence in humans, who are also infertile (hypogonadic) supports a slight increase in testosterone, but the solitary study in healthy humans smoothly failed to find an increase in testosterone
7.2. Estrogen
The two test quassinoids Eurycoma, 13α, 21-Dihydroeurycomanone and Eurycomanone in 17α-ethinylestradiol caused by examination uterotrophic (in vivo assay for antiestrogenicity [47]). [48] 2.44umol / kg was able to produce anti-estrogenic effects when injected, and although the impact was both showed more strength Eurycomanone, and tamoxifen was similar at the same molar dose effectiveness. But due to the low bioavailability of oral and weak eurycomanone Eurycoma content, and these effects can not be seen on the air. [14] Based on the molecular weight of 408.39916, [49] This is in line with a syringe of 996mcg of Eurycomanone (equivalent to 906mcg tamoxifen), and bioavailability of 10.5% [14] means nearly ten times the required dose to be biologically equivalent to a certain extent Big. And 30 mg of tamoxifen could theoretically be biologically equivalent to about 313 mg Eurycomanone (about 20 grams of dry weight of the plant).
These effects may lie behind some of the anti-cancer effects of Eurycoma, since it was found to prevent the proliferation of MCF-7 breast cancer cells in the laboratory, which is the hormone estrogen is very sensitive. [50] In addition, these effects may be anti-estrogen mechanism to increase sperm (sperm production) in males as a study in male rats treated with estrogen she pointed out that a low dose of 8 mg / kg of body weight walking stick given for 14 days He was able to suppress the repressive effects of estrogen in the cells and sperm count spermatogeic (normalization of them to control the levels), and Eurycoma in control without estrogen increased the number of sperm. It was noted the effect of estrogen abverse any increase in sperm motility even Eurycoma this parameter. [33]
Finally, a study on mice injected testosterone (in credibility cycles irregular and polycystic ovaries result) is given 50 mg / kg Libidus (TAF 273 concentrated extract Eurycomanone 23.6%) were female mice able to mitigate the negative changes injection of testosterone, and the normalization of the size of the vesicles ovarian health and work to normalize the abnormal credibility sessions (10-30% improvement of the rate cycle regular and credibility in the 40 to 62.5%, while it was 100% of control). I assumed [13] The authors of this was secondary to the work of anti-estrogen downstream of the conversion of testosterone but did not prove that the link. [13]
No comments:
Post a Comment