Cordyceps has been used in human trials within the scope of 1,000-3,000mg dose a day, either in a single dose or multiple doses with meals. There is no indication of whether this is the optimal dose or not, and it is not known whether this dose is still effective where it became part of the research zero.
Cordyceps mushroom is usually used to treat impotence and fertility in Chinese medicine as well as a general tonic and sexual libido enhancer / performance. [3] [4] This fungus belongs to the phylum Ascomycoa and cystic in the sub-family of languages, and class Clavicipataceae. Seen as a whole, and medical. [4]
There are several types of Cordyceps. Sinensis is the most commonly used species, is displayed on the Cordyceps to contain biologically active compound Cordycepin (3'-deoxyadenosine). It is also present in Militaris and kyushuensis. [4] [5] and the isolation of Cordycepin dating back to 1950, I discovered for the first time in Militaris. [6] It is known as Cordycepin nucleotide analog, due to structural similarities with adenosine. [7]
Cordyceps has a strong anti-oxidant, but its strength is very different from one sample to another. [8] anti-oxidant effects of Cordyceps content comes mostly polysaccharide, and powerful on an equal footing between the mycelium and fruiting body Cordyceps. [8]
Nucific Bio X4 Installation
Cordyceps, like mushrooms, and contains a variety of vehicles including:
Cordycepin, seen as the main biologically active, which is also known as 3'-deoxyadenosine [9]
Ergosterol and ergosterol palmitate [10]
"Cordycepic acid", which is only D- mannitol, [11] but some related compounds, such as 3,4-O-isopropylidene-D- mannitol [10]
(Sinensis mycelium) 25.5mcg glucosamine / ml (standard culture) and can be scaled to 13.1-29.3mg / ml [12]
(Kyushuensis) Sodium (15,238mcg / g) and potassium (23,860mcg / g), calcium (6248mcg / g) and magnesium (5630mcg / g), iron (556mcg / g) and zinc (32.9mcg / g)
(In adults selenium enriched mushrooms), selenomethionine, and selanate senelite [13]
Some bioactive amines:
Cordymin (MAPPYGYRTPDAAQ sequence of amino acids) [14]
"CMP" fruiting bodies [15]
Peptides containing alpha-aminoisobutyric acid [3] that is both soluble and non-water soluble components of water with properties similar testosterone increase [16]
Biologically active sugars
F2 polysaccharide soluble in water to 13.46% of the dry weight or less [16]
F3, soluble in water sparingly with a nitrogen content of 84.85% of the dry weight or less (that this study does not use pure) F3 [16]
CS-PS (12 kDa, mannose, rhamnose, arabinose, xylose, glucose and galactose to 38.37%, 2.51%, 2.21%, 5.22%, 27.44% and 24.25% of the total polysaccharide) [17]
CME-1, A mannose specific: Milk 4: 6 spingomyelinase polysaccharide is an inhibitor of [18]
CMP polysaccharide (polysaccharide extract is made up of 65.4% of the dry weight of Cordyceps) that the main biologically active part, CMP-II (16,7% of the dry) weight, with 56.4: Milk glucose ratio of 26.4: 17.2: mannose and 89.48% of the Gross weight sugars being [19]
Last polysaccharide (CPS1) with glucose: galactose: mannose, but in the ratio of 2.8: 1: 2.9 and 99% sugar by weight
2. nerves
2.1. Fatigue
150-300mg / kg of hot water extract of the fungus Cordyceps sinensis orally to rats (mostly carbohydrates), and the time it took for mice to become fatigued during the swimming test by one degree similar with both doses and was about (the value derived graphically) increased 12.5 %. [21]
2.2. Stress
And is linked to the consumption of 150 mg / kg of extract hot water for a week in mice with low vital signs to reduce stress in total cholesterol (effectively control stress normalization) and decreased decay in the spleen weight (24%), adrenal (91%) and liver (37 %). [21]
Bio X4 Impact on hormones
3.1. Testosterone
Cordyceps can reduce the generation of HCG and steroid stimulate camp (PKA and possibly by inhibiting P450scc 30%, the enzyme which converts cholesterol to pregnenolone). Showed [22] This same study that Cordyceps does not reduce testosterone production when incubated with co androstenedione, or pregnenolone, suggesting that does not affect the enzymes in the back of the steroid generation. [22] Interestingly, this study also showed that Cordyceps forskolin was able to prevent the generation of steroid-induced, and induced the camp and how Koleos forskohlii herb increases testosterone. [22] It has been observed that the inhibition of the synthesis of testosterone from stimulating the camp and HCG elsewhere, [23] [24] and PKA inhibition suppresses the effects of Cordyceps. [25]
Reception in stimulating hormone (LH), which is usually paid through the generation of steroid path depends camp, Cordyceps cells can suppress embrace this waterfall
In unstimulated cells intentionally HCG, and the removal of secretions Corcyceps increase testosterone reliably of cells with ideal concentration of 3 mg / ml, as shown in studies to respond separate dose. [16] [23] higher concentrations of 10 mg / ml are associated with low testosterone related baseline. [23] This protein fragments have been implicated in Cordyceps be active [16] vehicles, although Cordycepin seems to be active. [25] Food isolate Cordycepin to 40 mg / kg of body weight does not increase testosterone in vivo, however, still is the case when injected demonstrating the bioavailability of the poor. [25]
It was the opposite effect was observed in untreated cells through the LH receptor, and can increase the secretion of the hormone testosterone in these scenarios
It was found that the fungus Cordyceps militaris 1 or 5% by weight of the diet to increase circulating testosterone levels in mice after 6 weeks of supplementation. [26] During this period, body weight did not differ significantly between the groups, and the content of epididymal sperm by 53% and 37%, respectively, by 1% and 5% diet and increase traffic 31% and 19%. Serum testosterone rose to about 700pg / ml contact with fluctuating slightly less than 600 g / ml during the period of 6 weeks control. The peaks irregular and showed a tendency to significant difference in two weeks in a range of 5%, and cut to the baseline in the 5 weeks, and then nailed to be significantly different in 6-8 weeks; and it was from eating 1% stable relatively even were five Weeks was lying over and remained significantly different from control to stop in 8 weeks. [26] found another study on mice immature (without the influence of the hormone to stimulate the palaces of Central gonads) rose this 0.02-0.2g / kg body weight of circulating testosterone relatively equal (3.83 and 3.69 ng / ml, respectively) from baseline 1.38 +/- 0.047ng / ml [16] While soluble proteins are isolated parts water intake requires 0.2 g / kg of body weight. [16] Although these studies in mice are immature, and the study suggests no differences in the synthesis of testosterone in the immature and mature. [27]
And seen more dramatic peaks with intraperitoneal injection of cordycepin, and show increases testosterone makes them dependent. It was found that 40 mg / kg of body weight for 7 days in mice to increase testosterone +/- 2.88 0.19pg / UL 10.97 +/- 2.31pg / UL. The [25] This is the height of the commissioner through upregulation of A2A adenosine receptors (-7 three times) with a concomitant decrease in the A2B recpetor content [25] incubation company with a discount A2A receptors (in this study has been used CSC; Caffeine is a discount A2A popular) reduce the increase testosterone by 20%, but the inhibition of A3 reduced by 50%. [25] The final effect is that Cordycepin upregulates stolen enzyme, the transfer of cholesterol metabolism in the mitochondria to generate step in reducing the rate of steroid.
Cordyceps seems to increase the synthesis of testosterone in rats, and has multiple compounds that can do this (fragments of the protein, cordycepin); showing parts of the protein to be biologically related to 0.40 mg / kg oral Cordycepin do nothing to testosterone in rats but 0.2 mg / kg every Cordyceps regard. Cordyceps may have the organizational characteristics of testosterone, and testosterone is not blind nailing
3.2. Estrogen
Militaris Cordyceps supplements has been shown to increase levels of estradiol in rats fed 1% or 5% of its food and the mycelium, and despite the fact that a significant peak is observed after 2 weeks supplementation (of 30pg / ml range 60-70) and fell to the baseline at 4 weeks, and it remained different control is negligible. [26]
Bio X4 Follicle stimulating hormone
Despite the increase in mice sperm content, and do not have a significant impact on the follicle-stimulating hormone have seen with oral intake of Cordyceps 1-5 militaris% in the diet of male rats. [26]
3. 4. hormone
Significant effects on hormone levels not seen in male rats after oral intake of 1% or 5% Cordyceps militaris diet for 6 weeks traded. [26]
3.5. Prolactin
No more than 6 weeks of eating mycelium significant effects on prolactin either 1% or 5% dietary intake of Cordyceps militaris. [26]
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