Three separate studies of mice looking testosterone levels in the blood serum has a significant increase in circulating testosterone, and one study found a decrease in estrogen levels also. That said, it was exactly perceived increase testosterone reporting negative effects both in the liver and kidneys at the same dose.
What You Should Know
Also known as
Nucific Bio X4
ibhucu, rooiwortel, ingcelwaneTaking (the recommended dose, active and quantities, and other details)
Studies in mice that check how Ethyl reacts Bulbine with the observation that testosterone 50 mg / kg (10: Remove 1) seems to be the optimal dose and transfers based on the body surface, [8] and this is linked to an estimated 8 mg / kg or human dose:
550 mg of a person £ 150
730 mg of a person £ 200
900 mg of a person £ 250
These doses currently only estimates and within the scope observed in the trial of the only industry-funded Ethyl Bulbine this point in time (using 650 mg) [9] that the dose be 10 times if the use of raw plants. Without any particular extract.
Bulbine Ethyl Baker is a plant family that Asphodelaceae reported that her sexy characteristics aphrodisiac. It is also used topical juice plant for purposes such as burns and chapped lips while the use of aqueous extract of the leaves of intestinal problems (diarhhea, vomiting, seizures), has been reported to be used for the purposes of anti-diabetic and anti-inflammatory. It has been used by various cultures around where it grows (the northern and eastern sections of Africa) ingcelwane called in Xhosa, rooiwortel in Afrikaans and Zulu ibhucu. [1] [2]
Eleven. Installation
Herbal compound, Bulbine Ethyl which contain a variety of compounds or classes of compounds isolated. These include:
Saponins 1.97% of the dry weight [3]
Anthraquinone in 0.152% of the dry weight [3]
Tannins in 0.481% of the dry weight [3]
Cardiac glycosides in 0.887% of the dry weight [3]
0.2% alkaloids in dry weight [3]
2. interactions heart health
It seems that therapeutic doses of Bulbine Ethyl (25-100 mg / kg of body weight in mice) to be able to raise the circulating cholesterol and triglyceride levels, and cause minor changes in lipoproteins (HDL, LDL) to induce pro-State artherogenic. Can cholesterol levels in the blood increased 51.9%, 38.9% and 55.6% after 14 days of consumption, 25.50, and 100 mg / kg of body weight in mice, respectively, while the increase in triglycerides 115 and 8%, 82.5 % and 45.6%, respectively. [4] it has been observed changes in triglycerides, a day after the administration, and raised the hypothesis due to an increase in the decomposition of fat. [4]
While LDL was not affected, HDL cholesterol decreased from 1.73 +/- 0.07 mmol / liter to 0.90, 1.04 and 1.02 mmol / l in 25 dose / kg 50 100 mg group. Consecutive. [4]
Preliminary evidence suggests that, like a series of doping occasion, prolonged use of the most problematic Bulbine Ethyl becomes Profile your fat
3. interact with hormones
3.1. Testosterone
A study was conducted on Wistar rats fed Bulbine Ethyl (aqueous extract of the root), found an increase in circulating testosterone in doses of 25, 50 and 100 mg / kg of body weight of the male. [1] parameters of interest was not dose-dependent, and follows a bell curve. With 50 mg / kg of body weight is the most effective, followed by 25 mg / kg and 100 mg / kg of body weight. [1]
In the control group only less than 1 ng / ml testosterone, more effective dose (50 mg / kg) increased testosterone at about 3.3ng / mL (day 1), 4.2ng / ml (Day 7), and 4.4ng / ml ( 14 working days). [1] testicular testosterone levels came a similar pattern, and testicles of all the blood and the best dose was 50 mg / kg, followed by 25 mg / kg and 100 mg / kg. [1]
Other studies are looking at testosterone increases to account for up to 346% of the control level in male rats at 50 mg / kg of body weight, [5] although it is of 100mg / kg is associated with nonsignificant decrease in testosterone levels under control. [5] [3]
Properly it has been improved testosterone in rats, and also more very ability. However, it appears that doses higher than 100 mg / kg either strong in the 25 mg / kg or worse than nothing at all, and a decrease in testosterone. The dosage is very important here, and there are toxic bell curve
Mechanically, it is supplementing the active doses (25-50 mg / kg of body weight Bulbine Ethyl) is associated with increased activity of acid and alkaline phosphatases. [1] The phosphatase activity of enzymes associated to some extent with an increase in blood testosterone in the testicles. [1]
The expansion of the testis has been observed (2 to 2.9 times greater than the control) and increased glycogen and protein content and sialic acid in rats with testicular increase testicular testosterone levels, approximately 7-14 days after supplementation. [1]
Bio X4 Hormone
LH has been shown to increase with Ethyl Bulbine in male rats, and it seems more dramatic with the passage of time instead of a sharp impact. The only study that noted an increase LH was observed that the best dose (50 mg / kg of body weight) increased LH 2 ng / ml (with control in all parts of 0.6ng / ml) to 1 day, but 7NG / ml Day 14. [1]
It seems the hormone are not affected in female mice. [5]
3.3. Follicle stimulating hormone
Follicle stimulating hormone (FSH) in male rats also increases after Bulbine Ethyl consumption, similar to the hormone appears to be more effective in a longer period of time, but with less variation in time. [1] increase of 7 + / -0.2ng / ml 11.2 +/- 0.08ng / ml have been observed with the 50 mg / kg of body weight. [5]
It seems FSH can not be changed in female mice. [5]
3. 4. progesterone
The observed increase progesterone with 25 mg / kg (+31%) and 50 mg / kg (+70%). It is seen to decline from 41% with 100 mg / kg of body weight Bulbine Ethyl. [5]
Progresterone does not seem to be affected in female mice. [5]
3.5. Prolactin
Dose of 25.50, and 100 mg / kg of body weight in mice do not appear to significantly affect the concentration of serum prolactin in rats either gender. [5]
3.6. Estrogen
Estrogen seems to be squeezed in male rats after Ethyl Bulbine supplements decreased 79.7% control of 25 mg / kg, 65.1% of the control of the 50 mg / kg of body weight, and 76.7% control 100 mg / kg of body weight. Not affected [5] circulating estradiol levels in female mice. [5]
4. interactions bodies
4.1. Liver
The study found toxicology in mice that oral ingestion of 25.50, and was 100 mg / kg of body weight change and able to carry tissue changes known liver enzymes be adversely. [6] The negative effects in a dose-dependent increase over time, liver enzymes.
4.2. Kidneys
After ingestion of 25.50, and 100 mg / kg of body weight in mice Bulbine healthy Ethyl, and pointed histological examination of the kidney tubes (both near and twisted) abnormalities in the structure which may be indicative of some toxic effects. [6]
5. Interaction with the sexual organs and fertility
5.1. Testicles
After supplements of 25-100 mg / kg per day Bulbine Ethyl mice for 14 days increase the size of the testicles, which increases the testicular :. [1] Another study found notable increases in testicular size with the same body weight ratio of 0.35 to 1 doses more than 14 days in the 50 mg / kg to the epididymis, seminal vesicle and prostate did not increase in size. [3]
It is also able to increase testicular glycogen content (in time rather than acute) and sialic acid content, protein content and cholesterol content (all large increases in Day 1, and thus sharp). [1]
5.2. Sexuality and lust
A oral doses of 25-50mg / kg body weight, and it seems Bulbine Ethyl to have a sexy aphrodisiac effects may be secondary to the testosterone. [5] These effects aphrodisiac, when given to 25-50 mg / kg of body weight doses, are more effective than Viagra in 50 mg / kg of body weight. [3]
Surprisingly, it has affected sperm parameters such as movement, and viscosity, and morhpology at all doses tested Bulbina Ethyl. [5] noticed other functions related to sexuality and testosterone, and increasing swelling of the penis, and a decrease in ejactulations refractory period also with Ethyl Bulbine supplements. [3]
Bio X4 Safety and Toxicology
6.1. Public
Ethyl Bulbine does not seem to change the image of red blood cells (toxicology test standard) in healthy mice, but may alter white blood cell population. [4] dose of 25.50, and 100 mg / kg of body weight during the 14 days may increase white blood cells (WBC) by 41.9%, 26.1% and 38.5%, respectively. [4] levels of neutrophils, the basal cells, eosinophils and lymphocytes decreased, while monocytes and platelets increased.
As mentioned in the hardware sections, it seems Ethyl Bulbine adversely affect the structure of the liver and kidney doses used to increase testosterone. It does not seem to prostate bodies and "masculine" related as if it has been adversely affected. [6] [5]
Preliminary research on humans (if any poster here, [7] financial support of Sport Nutrition LTD produced proven extension Research) taking 325 mg of Ethyl Bulbine twice daily (total 750 mg, separated 6 hours) for 28 days in healthy men observed an increase minor in ALP (2%, while placebo decreased 2.4%), which is regarded as clinically relevant.
It seems that the repetition of non-lethal toxic effects that appeared in one rodent research group based in South Africa, while pointed Bulbine solo human study (which is supported financially by Bulbine product) increase in liver enzyme ALP, which was not clinical dramatically.
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