1.3. Formulations and variables

Nucific Bio X4 Formulations and variables

Maca refers to a process known as gelatinisation of starch in Maca powder is heated in water to form a group of polymers in solution, [22] and claimed to increase the digestion and bioavailability of supplements appeal compared to the raw powder.

There are currently evaluating the impact of this process on the activity of Maca that are relevant as studies are known glucosinolates to be sensitive to heat, while the immunological effects of the appeal back to the carbohydrate content (active carbohydrate biology underlying many of the benefits seen with supplements and immunity, lucidum Ganoderma Astragalus membrane).

Popular form of appeal that have not been studied, and it is not known how this process affects the complement activity. No evaluation of claims relating to appeal to digest this way with respect to the raw powder.


2. nerves

21. Bah

Mechanically, the study investigated whether there was a relationship between hormones and Bah failed to find any relationship can be found on any Bah peak of hormones in the study population, despite being present. This study suggests that the mechanisms of appeal Bah not mediated by hormones. [23] This sexy effects of aphrodisiac also appear to be independent of the ability appeal to induce motor activity, where the study mice to find benefits for installation and cumin access and intercopulatory interval (not dose dependent) latency and after ejaculation any clear correlation with the observed motion increase ( up to 75 mg / kg dose dependent). [24]

Active ingredients can be macamide element (fat), and extract fat scheduled to be biologically active. [14]

Independent of any normally involved in the mechanisms Bah hormone (testosterone, estrogen, the hormone, etc.) and other neurological effects Maca
A study published in mice compared to the acute effects of appeal against chronic doses Note that after the aqueous extract 25 or 100 mg / kg in mice consumption, a single dose before sexual activity 30 minutes failed to increase the pool or ejaculatory parameters in rats. [25] A week after measurements began the trend toward significant improvements, but for a week, and after 21 days, these differences were not statistically significant. [25]

Maca root seems to be a way Bah "accumulation", with greater efficiency that comes from repeat dose once independent about sexual activity
In healthy men take the 3G daily 1.5go Maca, Aphrodisias (through self-determination) and by 24.4% .40%, 42.2% and in 4, 8 and 12 weeks. Consecutive. In this study, 16.6% of the Bah reports and placebo was observed in Week 4, which did not happen, either at week 8 or 12. [23] As noted this aphrodisiac effect in athletes, which was experienced in good health, as 2G 5: 1 Maca extract taken for 2 weeks was associated with better scores on a scale rating sexuality (sexual desire inventory [26]), with further improvement observed with dynamic libido (sexual desire for others) rather than solitary sexual desire. [27]

In men who suffer from erectile dysfunction moderate, both Maca (2400 mg) and placebo led to significant improvements in scores of IIEF-5 (rating scale for erectile dysfunction), but the rate of increase seen with Maca much better than those observed placebo. Maca appeared to be stronger in those with poor scores. [28]

And conducted the test using the root Maca, where he was recruited outpatients with depression (17 women and 3 men) for 10 months to be the conditions are met to address sexual dysfunction antidepressant caused by use of 1.5 grams a day the 3G to appeal to the 12-week and indicated that, according to MGH-SFQ's [29] and was ASEX [30] questionnaires significant improvement in both groups a dose, more effectively than in high doses of Maca. [31] libido up to the importance according to a survey conducted (ASEX), and sexual enjoyment is increased self-reported. [31]

Human interventions, it seems to show statistical significance in a variety of different sub-groups of the population

Bio X4 Anxiety and depression

Subject to forced swimming test given 1G / kg female mice is Maca Maca has anti-depressant effects, and the reduction of inertia of 76.4 to 87.4% of the base. [9] Note also that this study that despite the yellow and red appeal to exert antidepressant effects that Black Maca was slightly more effective. [9]

Study on mice indicate anxiolytic effects due to the high performance test as well as a maze. [25]

It was noted the presence of the reduction of depression and anxiety in women after menopause who take Maca 3.5G daily for 6 weeks, and assessed by the lateral branches of which Greene critical scale. [32]

Human studies are mixed, but the appeal may help anxiety and depression take stress or preexisting case

2.3. Memory and cognition

/ Kg of Maca (red, yellow, and black) compared to three forms in female mice study shows getter ovary using 1 g to improve cognition as assessed by the task of finding water with black beating other variables. [9] used a similar task with Black Maca in a test to see the effects of nerves against scopalamine, I found the deal tend to appeal to groups (not significant) to overcome the control. [33]

It is to show the trends to improve cognition in otherwise normal mice, but the mechanisms are not very important and unknown
In the study injected scopalamine (who pays acetylcholine) were found to suppress the increase to the level of AChE Maca is not much different than placebo [33] was able to reduce the increase in AChE in mice menopause. [34] found no effect on oxidase activity [33] that has been replicated [34] This observation is the result of a sudden because of some compounds β-carboline [20] has been associated with the inhibition of MAO previously. [35]


2.4. Neurological

One tested in the laboratory with cancers and pointed neurons isolated dose-dependent protection against hydrogen peroxide when it was pretreated neurons 3 hours before treatment H2O2, and the extraction of pentane appeal and EC50 approximately 2.8 micrograms / exerted protect ml and 88% when used 30μg / ml [36] When tested in vivo, injection of 3 mg / kg of body weight pentane Maca extract a significant reduction in the size of myocardial ischemia (indicate protective effects l) 58.6% of the volume control; high doses (10.30 mg / kg) actuall exacerbate the damage. [36]

Black Maca on a form of memory impairment caused by alcohol when it was administered both orally for 28 days to note the study varying doses (0.125, 0.25, 0.5 and 1 g / kg) that all doses Black Maca they were able to cancel the increase in latency Escape (the time required for mice to eliminate the maze itself) is seen with alcohol, and a trend to improve soon to control. [37]

It was noted protect Scopalamine with Black Maca, [33] feeds this study both aqueous (0.5 0.2 g / kg) and water alcoholic (0.25 0.1 g) extracts for 35 days and poison injected scopalamine acetylcholinergic before the test, and proved that the administration appeal was able to prevent caused by scopalamine reduction in performance (through a maze test Morris) is no difference between extracts or dose, but in less than extract all directions to overcome the control doses. [33]

It seems that a powerful nerve agent, and that seems to appeal to black and other environmental models nerves. Currently we do not know what the reason

Bio X4 Cardiovascular Health

3.1. blood pressure

Currently, the study suggests that the appeal may have the blood pressure by reducing the ACE inhibitory activities dose-dependent manner, with overcoming the heat treatment to extract crude oil extraction properties. [7] He said that the preliminary study of toxins with 0.6 grams per day Maca noticed a small but significant increase in diastolic blood pressure. [38]

Interaction with cardiovascular health is currently unknown


4. interact with the glucose metabolism

4.1. Absorption

The appeal for its ability to prevent the absorption of carbohydrates in the intestines, and in vitro evaluation of both raw and roasted test extracts Maca study noted (in the inhibition of α-glucosidase and α-amylase) Note that both the appeal of crude extracts prevents inhibit α-glucosidase in the range of 20-40% ( weak), while crude appeal to prevent the weak α-amylase (about 10%), while Maca roasted failure to prevent the α-amylase. [7] These results are not associated with the polyphenol content of the appeal, which was poor.


4.2. Speeches

A study carried out on mice using Maca at 1% of the food weight in an animal model of triglycerides inheritance (aggravated by a diet rich in sucrose for two weeks) that the appeal was able to reduce the cholesterole plasma (LDL-C and was reduced VLDL-C), as well as triglycerides and glucose (thought to be secondary to lower triglycerides). Used [39] This study rosiglitazone 0.02% as an active control, which exceeded appeal. [39]