The ring, known as the ring, is an herb popular in the Arab region and India. Traditionally it has been used to improve sexual desire and masculinity.
Nucific Bio X4
Fenugreek has also been used to relieve the metabolism of blood sugar problems, like diabetes.Tea has also been recommended a new arena for mothers to improve milk production. Although the evidence for this claim is limited, and it seems to be accurate. A study conducted in humans have shown that supplements may also increase testosterone ring, but additional evidence shows mixed results, and there is a need for further tests to confirm this sense.
More famous ring compound is 4-hydroxy isoleucine, which works on the normalization of glucose metabolism. And other compounds, called Trigonlen, galactomannan and trigoneosides also work together to provide the benefits of sugar in the blood.
Fenugreek supplements can cause body fluids, including urine, smell like maple syrup. This is due to a metabolite called sotolon.
Taking (the recommended dose, active and quantities, and other details)
Fenugreek doses vary according to the objectives of the supplements.
Should new mothers who want to increase breast milk production aims to 500-1000mg ring. Men who want to increase libido or testosterone may consider taking between 500-600mg formulate a unified circuit, such as the commonly used product called 'Testofen. Fenusides Testofen 50% by weight.
Fenugreek seeds are extremely versatile. They can be eaten seeds and made into tea, it turned into flour and bake bread in, or pressure in the oil. Eat the seeds or the use of flour the ring is the most effective way in the ring to control blood sugar. Oral dose of 2.5 grams of fenugreek seeds can help in blood sugar levels for diabetics.
Trials in the ring, it usually takes on a daily basis.
1. Origin and configuration
Eleven. Resources
Fenugreek seeds and stems of the plant extract of the ring L and historically used for different uses, as an antispasmodic, appetite stimulant, high cholesterol, and wounds, and blood cleanser, and the effects of expectorant. [2] [3] It is derived from each of Ayurveda (the majority) and traditional Chinese medicine (to a lesser extent) [3] Unlike most conventional drugs that seem to spices. [3]
There are some other traditional uses of seeds including the use of beer fenugeek as a home remedy for anxiety and despair (Danish). [4]
1.2. Installation
Fenugreek seeds (fenugreek seeds, the main active ingredient of this plant) tend to contain:
Trigonlen, betaine molecule also found in high levels in alfalfa and coffee [5]
isoleucine- 4-hydroxy [6] and the precursor 0.2-Hedrgen Alooksoglotarat. [7]
Protodioscin [8] Like terrestris
And two Trigoneosides, Trigofaenoside A and D glucoside [9] [8]
Diosgenin [8] [10] and yamogenina [11] [8] [11]
GII, a compound name for the time being. [12]
3-hydroxy -4.5-dimethyl -2 (5H) -furanone (aka sotolon; HDMF), the causative agent of maple syrup smell of secretions from the body [13] [14]
Small, such as acid Alcavic 85.50ng / mg (ethyl acetate extract) or 31.25ng / mg (aqueous extract) phenol [15] quinic acid 15.97ng / mg (ethyl acetate extract) 165.55ng / mg (aqueous extract), [15] and gallic acid in 3.93ng / mg (ethyl acetate extract) or 3.10ng / mg (water extraction) [15]
APIGENIN-7- O- glucoside (1955.55ng / mg extract in ethyl acetate [15])
And Teulen-7- O- glucoside (725.50ng / mg extract in ethyl acetate [15])
Vitamin C in 576.50ng / mg (ethyl acetate extraction [15]) and less in water extraction (6.82ng / mg
Bio X4 Minerals such as potassium (603 +/- 15 mg / 100 g [16]) and magnesium (42 +/- 5 mg / 100 g [16]), calcium (75 +/- 9 mg / 100 g [16]) Zinc ( 2.4 +/- 0.2 mg / 100 g [16]), and iron (25.8 +/- 1.2 mg / 100 g [16]), both manganese and copper (0.9 + / - 0.1 mg / 100 g [16])
It has also been found to possess the ring chymotrypsin and trypsin inhibitors (protein digestive enzymes). [17] [18]Fenugreek extract crude ethyl acetate has the highest antioxidant properties of all excerpts from the show ring. [fifteen]
Carbohydrates, dietary fiber (the latter which is 6.28 even 9.3% of the total seed weight [19]) as follows:
Soluble fiber also galactomannins [20], with milk: mannose ratio of 1.5: 1. [21]
Component of the fatty acids of the ring (4.51 until 7.1% of the dry weight in general [16] [19]) and consists mostly oleic segment (16.3%), and linoleic (50%) and linolenic acid (24.4%). [22]
Oil ring (aromatic component) that has neryl acetate (17.32%), camphor (16.32%), β- pinene (15.05%), β-caryophyllene (14.63%), 2,5-dimethylpyrazine (6.14%), geranial (4.81% ) 0.6-methyl-5- hepten-2- one (4.48%), 3 octen-2- one (4.32%), α-selinene (4.04%), α terpineol (2.77%), α-Campholenal (2.63% ), α- pinene (2.61%), and γ-terpinene (2.08%). [2. 3]
Protein content in the seeds themselves seems to be 12.9 to 28.4%, but is highly variable. [16] [19]
1.3. Normalization
Alcoholic extract standardized for fenugeek biologically active isolated Trigonlen called SFSE-T. [24]
2. Pharmacy
21. Drug Interactions drug
Fenugreek (300 mg / kg of seeds powder for eight days with the final one hour before the test dose) should not react significantly with CYP3A4 according to the assessment of the carbamazepine tracer test. [25]
At this moment in time there are no known interactions with CYP3A4 enzyme activity
Fenugreek (300 mg / kg of seeds powder for eight days in rabbits with the final dose one hour before the test) failed to interact significantly with the function of P- glycoprotein according to the evaluation of the plotter test cyclosporine. [25]
There seems to be no inhibitory or inductive property in protein efflux P- glycoprotein
3. Neuroscience
3.1. Mechanisms
Ethanol extract of fenugreek seeds appears to prevent oxidase A (MAO-A) with IC50 of 4μg / ml [4] and extract contains high levels of trigenolline (84%) showed MAOI properties with IC50 of 528μg / ml (assuming pure trigenolline 2.81μM ). [24]
Extract high trigenolline has been observed (84%) to prevent oxidase B (MAO-B) with IC50 of 391μg / ml (assuming pure 2.1μM trigenolline). [24]
Fenugreek seeds have the ability to prevent all forms of the enzyme monoamine oxidase (MAO) with no obvious sensitivity. This may be related in part to trigenolline content, but may be more powerful molecule capable of inhibiting MAO-A in the extraction of ethanol
Bio X4. Cholinergic nervous
A study in the laboratory using a crude extract of the ring retardant properties acetylcholine [26] with IC50 value of between 9.23 +/- 6.08μg / ml (pure) and 53 alkaloids +/- 17.33μg / ml (ethyl acetate extract). [26]
Ingestion is not proven by the mouth of 10-100mg / kg of extract of fenugreek seeds (82% trigenolline) anticholinergic effects in mice (a model of Parkinson's disease). [24]
3.3. Nervous hormone serotonin
It did not prove to extract ethanol from the ring affinity for serotonin transport (Sirte) at concentrations up to 10 mg / mL, which indicates that there could be used as an SSRI. [4]
Fenugeek seems to have no affinity for serotonin transport
It is well known the ring to practice analgesic properties when injected in the vicinity, and when the system is the hormone serotonin damage irreversibly the backbone (injection 5,7-dihydroxytryptamine) analgesic properties canceled low doses of the ring and increase the dose reduced. [27]
Hormone serotonin signals appear to be involved in the analgesic properties of the ring in the vicinity
3. 4. appetite
Study on mice using 42 mg / kg ring is proposing an increase in appetite [28], which have been replicated in humans in the 40 mg / kg of body weight of the aqueous extract in healthy volunteers. [29]
In obese people, the ring (1176mg) taken daily appeared to reduce the intake of fat spontaneously without affecting significantly the global appetite [30] [31] while the isolated fiber (4-8G) appear daily to induce satiety in people suffering from obesity excessive. [32]
It has been implicated in modulating appetite, and has had a growing impact on people of normal weight (Association unknown whether normal weight is a prerequisite mandatory) and either satisfactory or any stimulating effect in obese people. One study has noted at least appetite preferential shift away from food fatty acids
3.5. Soothing
Injection circuit (500-2,000μg intrathecally or peritoneal 1 g) seem to have analgesic properties in mice mediated through serotonergic system in the spine, [27], which is a similar mechanism of action of NSAIDs such as aspirin [33] [ 34] and can prevent organ hormone serotonin spinal damage with the injection of 5,7-dihydroxytryptamine [27] or prevent the synthesis of serotonin with parachlorophenylalanine. [3. 4]
A fenugreek seed extract (IND01) orally to the mice in the 50-200mg / kg for a month after spinal nerve damage (either partially sciatic connect nerves (PSNL) or crush injury of the sciatic nerve (SNCI) injury) shown to reduce the lesions caused by the two weeks after that or supplements, but not two days hyperalgesia. [35] / kg and the extent of awareness with 200 mg IND01 signal similar to 100 mg / kg of pyridoxine hydrochloride. [35]
4. Cardiovascular Health
4.1. Absorption
In the intestine, can component fiber from fenugreek seeds suppress the absorption of cholesterol and bile acids. [36]
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