Today, Koleos forskohlii is used as a supplement to burn fat.

Nucific Bio X4

Today, Koleos forskohlii is used as a supplement to burn fat.

The so-called main ingredient biologically active Koleos forskohlii forskolin. By forskolin, Koleos forskohlii supplements may increase testosterone, and protect against cancer and infections. There is a need for more research to confirm these effects, and are often used this forskolin as a research tool in the laboratory, or outside the body, as is the case in a test tube or petri dish. Forskolin could behave differently in the body.

Forskolin enzyme levels of cells called cyclic adenosine monophosphate increases (camp). And linked to high levels of the camp with high rates of fat loss, and can enhance the effects of other compounds to burn fat.

Still under investigation Forskolin to their effects on testosterone and fat loss, but the initial results are promising.



What You Should Know
Also known as

Forskolin, Coleonol, -7beta acetoxy-1 alpha, 6beta, 9alpha-trihydroxy-8,13- Aliboksa- CHA-14-EN-11 one
1. Origin and configuration

Eleven. Source

Koleos forskohlii family of oral Family (alternative name Plectranthus barbatus) Ayurvetic is a medicine commonly used for various heart nervous system and cardiovascular diseases, gastrointestinal and central. [4] It also has some implications on lung health and urinary health. [5]

And it includes other names Koleos "Boldo Zor" (in Brazil [6])

Bio X4. Installation

Pneumatic parts of the Koleos forskohlii (leaves and stems) as follows:

Forskolin series of related compounds (A, G, H, I, J) and isoforskolin [7] [8] [9] [10] forskolin main compound used in the research has the technical 7beta name acetoxy-1 alpha, 6beta, -9alpha trihydroxy -8.13 Aliboksa--CHA-14-EN-11 one. [Eleven]
And Forskoditerpenoside (A, C, D, E) of the diterpene chain structures. [12] [13]
(16S) -Coleon E [6]
4beta, 7beta, 11-enantioeudesmantriol [13]
Rosmarinic acid (leaves) [14]
diterpenoids Abietane [15]
Chamaecydin [7]
Scutellarein as 4'-methyl-7- O- glucuronide [6]
As Teulen 7-O- glucuronide [15]
APIGENIN and 7-O- glucuronide [15]
Acacetin for 7-O- glucuronide [15]
Alpha cedrene [7]
Oleanolic [7] acid and Btewolenk [7]
And beta-sitosterol [7]
While pane contains the root:

14-deoxycoleon T [16]
Demethylcryptojapnol [16]
Alpha Alpha amyrin and Cedrol [16]
Btewolenk acid [16]
And beta-sitosterol [16]
It is usually used for the active ingredient, forskolin, direct tonic intermediate cell called flying aloft. [17] also it called Coleonol, Forskolin found in concentrations in different plant Koleos forskohlii degrees. [5] a powder umber when completed, and its smell fragrant but bitter taste. When completed, full color factory is more brown in appearance. [5] Forskolin has a solubility in water is low, but it was quite unstable. [18]


1.3. Variables and fixtures

Forskolin itself has a poor water-soluble, and 8 of 9 Aesfurmes activates adenylate cyclase. This is considered undesirable by some, such as an increase in the camp of other members of the target device can lead to unexpected side effects. [19]

Has developed derivatives Forskolin, FD-1 (6- {{2-N- isothiocyanatoethyl}} aminocarbonyl forskolin) has convergence of receptor II, III, V type lesser degree. 5,6-dehydroxy-7-desacetyl-7-nicotinoylforskolin seems (FD-4) to have a high affinity for the third type, and there is a difference between the second and fifth and finally, 6- {3- (dimethylamino) propionyl} 14 15 -dihydroforskolin seems to have a high affinity V type to the second type, with slight effects on the type III. [19] This is the relevant second type information is everywhere (everywhere), the third type is more tissue sense of smell, the atria and fat brown and V type large isoform is a form of adult heart tissue. [20] [19] Some of these powers Aesfurmes related to a range of 1-300% forskolin matrix. [19]



2. molecular targets

Nucific. Adenylcyclase

Forskolin is to stimulate adenylate cyclase (synonym of adenylate cyclase), which increases the levels of cyclic adenosine monophosphate (camp) in the cells. [21] [17] It is an agent highly reliable and effective increase camp, and is routinely used as a research tool to investigate the effects of the increase in the camp cells. [Eleven]

Increase this camp no more than the decomposition of fat per se in low concentrations 0.1-1μM, but when it exceeds 10 .mu.m can be analyzed fat itself occur. [21] low concentrations effective to increase the decomposition of fat when combined with β2- adrenergic receptor agonists, which shows the fat burning effects of forskolin rely either high-dose or costimulation with others (exogenous and / or self) agents. [21] along the lines of costimulatory effect of agents that stimulate usually flying aloft, which can suppress the drug targets in nature adenylate flying activity as α2-adrenergic stimulation or insulin can suppress activity forskolin to increase the camp. [22]

Forskolin can activate adenylate cyclase to increase the levels of the camp in the cell, and is added with other factors that increase the time the camp. It can be self-molecules or nutritional supplements that have worked on the repressive camp (via the suppression of adenylate cyclase) suppress the activity forskolin

2.2. Increase camp

This mechanism is similar to the increase in camp make for the activity of certain enzymes, downstream of the mitochondrial biogenesis (also, nonsignificant increase in mitochondrial density in 4um forskolin) to increase. It seems [23] This camp increased capacity forskolin also not significantly activate AMPK. [2. 3]



3. Pharmacy

Bio X4. Absorption

Koleos forskohlii well absorbed from the gastrointestinal tract after oral cat [24] and the administration can be absorbed in all areas of the intestine and colon (rat), in spite of the duodenum seems to increase absorption. [25]

Forskolin appears to be subject to P-glycoprotein efflux in the intestines, and coingestion of inhibitor for P- glycoprotein may increase the bioavailability of oral. [25]



4. neuroscience

4.1. Nervous Adenosinergic

The study found that indicates adenosine necessary forskolin (1 um) to increase the camp in slices of rat cerebral cortex as addition of caffeine able to curb forskolin with IC50 of 21 +/- 3μM. [26] [27] and this is probably due to signs of adenosine receptors characteristics, such as increased adenosine [28] [29] or other stimuli of adenosine [29] out of the cell increases the energy forskolin, while theophylline (twice the receptors adenosine) has implications much weaker. [26] When tested in cells Amon century while it seems that activation of adenosine A1 receptors suppresses the accumulation of AMP forskolin from A2 receptors stimulate; [29] replicated in the cerebral cortex slices [30] [31]