Boron Taking (the recommended dose)

Nucific Bio X4 -4 in 1 Probiotic

Taking (the recommended dose, active and quantities, and other details)
Less effective dose of boron supplementation appears to be 3 mg, which is effective in supporting the hormonal parameters in women after menopause. Studies have used osteoporosis 6 mg of boron while studies used hormonal changes young research 10mg.

Currently the optimal dose is unknown, but previous dose seems to be active for the aforementioned objectives.
1. sources and structure
Boron metal food which, although it contains a daily intake, were not accepted as an essential vitamin or mineral. Nowadays there are minimum requirements met.


1.1. Resources

The most important sources of boron in the diet are fruits and vegetables and root crops and drinking water. [1] it is also used in some industrial products, and the possibility of increased serum boron likely secondary to these, especially if. Contact wounds [2] Good sources of boron are: [1]

Avocado (about 1.11mg / 0.102mmol by avocado) [3]
Onions and dried flakes (6,573 +/- 3.228mcg / g)
Ground cinnamon (10.37 +/- 0.661mcg / g)
Parsley (26878 +/- 1.778mcg / g)
Apple juice (1,881 +/- 0.082mcg / g) and salsa (2,828 +/- 0.12mcg / g)
Cherry (1482 +/- 0.243mcg / g)
Grape juice (2.020 +/- 0.265mcg / g)
Peaches (1,872 +/- 0.112mcg / g)
Beef Boullion (1,264 +/- 0.609mcg / g)
Ice Cream (0,192 +/- 0.03mcg / g)
Flour (0.275 +/- 0.139)
Enriched corn flakes (0.314 +/- 0.079mcg / g)
Enriched white bread (0,202 +/- 0.07mcg / g)
Stalk of broccoli (0,889 +/- 0.039mcg / g)
Products with a small (less than 0.015mcg / g) are: [1]

Beef and chicken
Except dairy ice cream
Corn Starch
Rice
Spaghetti
Gelatin, puddings, or sugar

1.2. Biological importance

Boron is a mineral which is also involved as the Lewis acid, bound for a hydroxyl (suit antioxidant, but it is likely to be minimal given the small quantities of boron de novo); boron when turning to three hydroxyl groups, it is known that the structure of the name of boric acid or acid Boric. [4]

Nucific Bio X4 Pharmacy

2.1. Absorption

Boron seems to be absorbed by the intestines and is reported to be almost complete [5] 84% of the radiolabeled dose was found in the urine after an oral dose of 10 mg in healthy people. [6]

It is believed that passive transport may play a role, as boron metalloid is the smallest known [7] (This has been observed in plants [8]) Although plants have also shown that boron accept tankers selectively. [9] [10] was identified respect to the carrier by the mammalian sodium borate (NaBCl or SLC4A11) in mice [11] pigs [12] and human intestinal tissue [13] and it is sensitive to boron diet. [12]

Boron seems to be well absorbed from the intestine, and this may be due to be absorbed (such as borate) through transmission known as SLC4A11

2.2. Serum

Oral boron 11.4mg (by 102.6mg sodium tetra borate decahydrate), along with the meal can lead to increased plasma boron in one hour peaking at 4 hours after consumption; [14] fluctuated 0.008-0.016 mg / L in the placebo after nailing 0.058mg / L in 1 hour peaking at 0.136mg / L after 4 hours. [14] This study can not be observed difference in the urine concentration of boron for 2 days combined. One study measuring the effects of boron observed in serum was that boron supplementation of 10 mg standard capable of influencing the biomarkers selected according to the same schedule (with the peak in 4 hours and some effectiveness in 1 hour). [fifteen]


2.3. Removal

It has been observed that dietary intake levels of boron is lost through the stool minimum (2%) with other urinary tract and lost to some extent, through sweat and breathing. [5] [16]

A study in postmenopausal women given supplemental boron 3mg that most of the supplements was born excreted (mainly via the urine), who could not bear the idea that boron accumulates in the body. [17] It has been observed and boron extremely rapid excretion through the urine elsewhere in humans. [18]



3. neuroscience and brain

3.1. Shortage

Boron deficiency (less than 0.23mg calories a day) seems to change brain wave activity. Increase the strength of Delta in the left parietal and temporal lobe and decreased activity in the frontal lobe. Like the results of the deliberate lack of magnesium. [19] This case is linked to the lack of suffering from cognitive impairment when combined with a sufficient amount of 3 mg or more [20], which may be associated with boron participate in stabilizing the membrane of nerve cells. [21] [22]

You can play a role in maintaining the function of nerve cells, but there is no evidence to support the intervention supplements now


4. Performance interactions


5. glucose metabolism

5.1. Speeches

Oral 11.6 mg of boron without affecting the plasma insulin or glucose levels after a meal test in spite of boron being increased serum. [14]



6. bones and skeletal mass

6.1. Osteoporosis

I've been to assume that the 6 mg per day Burrow (tetraborate) may relieve arthritis, [23] which was followed by a pilot study in 20 patients with osteoporosis confirmed showed 50% response (half of the patients reported that they profit) with tetraborate sodium decahydrate 55 mg (6 mg elemental boron), which refers to the possible benefit for osteoporosis. [24] This may be relevant to note that the bone and synovial fluid of people nervous disease is less than healthy. [2. 3]


6.2. Speeches

In a single-blind study evaluating all of women's sportswear and stable because women 3mg boron (mixed aspartate dogs, jackets, glycinate) daily for 10 months in conjunction with dietary boron enough, and has been associated with boron with a slight decline in circulation of phosphorus levels (1.5 mmol / l reduced to 1.3 mmol / l in sports, 1.7 mmol / L reduced to 1.4 mmol / l in the sitting). Any significant impact on the levels of calcium or magnesium in the blood serum [25] seems to be urinating phosphorus reduction and a slight increase in calcium in the urine only women athletes. [25]

When you have a magnesium deficiency, supplemental boron still appears to reduce the urinary phosphorus levels, [26] the reduction of calcium in the urine has been observed in women with low intake of dietary magnesium in another study, this was not observed with the administration of magnesium supplements (and not the poor ). [17]

Bio X4

 inflammation and immune

7.1. Cytokines

6 days of supplementation of 10 mg of boron able to reduce serum levels of TNF- at 19.1%, high-protein and C-reactive sensitivity of 45%, and IL-6 43.9% in healthy men. [fifteen]



8. interact with hormones

8.1. Testosterone

Mechanically, the concentrations of boron are not linked to the mixture in the lab with testicular androstenedione to testosterone conversion rates. [27]

In healthy men, according to a study that the sharp boron supplementation in the period of 6 hours, can not total testosterone levels increases still tend to increase free testosterone (14.7%) and DHT (+ 9 9%), although not statistically significant , however, significantly reduces the sex hormone binding globulin (SHBG) 9% mark in 6 hours but it takes two hours to reach significance. [15] After 7 days of supplementation, and reached the increase in free testosterone (28.3%) the importance However, the decline was not SHBG. [15] Another study with 4 weeks of supplementation with 10 mg of boron noticed a trend towards increasing testosterone (11.4%), but did not reach statistical significance. [6]

The study was conducted on men involved in the sport of bodybuilding, using a lower dose. 2.5 mg of boron per day for 9 weeks high levels of boron plasma (20.1ppb to 32.6ppm, an increase of 62%), but there are significant differences between the groups of measurements [28] hormones.

In healthy adult males, Boro mobile seems to have mixed results. It has been implicated in increasing testosterone, but this can be time-dependent or dose of lengthy studies with the same or less stop repeat dose increase in free testosterone seen in study
In postmenopausal women with a diet deficiency in boron (0.25 mg daily), 3 mg supplements can maintain low in the diet caused by testosterone. [26] This increase looks larger than its size when dietary magnesium was low, suggesting boron may work on similar mechanisms.

Boron deficiency appears to reduce the case of androgen in women, and can restore levels of efficiency; a similar phenomenon as we have seen with zinc
A study toxicology in mice that, with respect to testosterone more than 30 days to note that there is an increase in testosterone dose-dependent manner up to 122% rises (2000 ppm), but the progress of toxic invested more than 60 days increased hormone Testosterone at the top of the group fell while witnessed the lowest group (500 mg), an increase of 10.5% on the day 30 increased this to 158% in 60. [29] today These results indicate that the accumulation of boron in the testes contributes to the increase of testosterone, time or the dose may be contributing factors, it has been replicated in 25 mg / kg for 6 weeks (toxicity) while 2-12.5mg / kg was associated with improvements in testosterone. [27]


8.2. Estrogen

In male healthy adults 0.10 mg of boron per day for a week significantly reduce serum estradiol (estrogen) of 42.33pg / ml 25.81 pg / ml for (39%), although no significant effect was seen after one dose when measured after 6 hours. [15] On the contrary, I found another study found 4 weeks of 10 mg boron increases in serum estradiol 51.9pmol / ml 73.9 pmol / L in 18 healthy men's. [6]

Two studies on men and estrogen with dichotomous outcomes the same dose in the same population
In postmenopausal women who follow the diet boron deficiency, supplementation of boron to 3 mg / day are able to maintain estrogen levels drop during boron deficiency. [26]


8.3. Hormone

10 mg of boron per day for one week does not affect significantly LH in adult males [15] and variable dose in mice at doses ranging from toxic also fail to influence LH. [29]


8.4. Follicle stimulating hormone

In rats fed 500.1000, or 2000 ppm boron for 60 days, it was noted the existence of time and increase the dose depends on the FSH in all categories. [29]

Bio X4 Cortisol

After a week of 10 mg boron supplementation in healthy men does not affect cortisol. [fifteen]



9. interactions organs of the body

9.1. Testicles

Rat study indicated that higher doses (associated with testicular toxicity) may testicular high concentrations of boron, which indicates either boron selective accumulation in the testes or perhaps was skewed because of the concentration of testicular atrophy. It was not observed it with a dose less than 500 ppm. [29]


9.2. Prostate

Evaluation of a cohort of 35 222 832 women with confirmed prostate cancer case control more than 3 years, it was observed that the highest quarter had not been significantly protected against prostate cancer, compared with at least a quarter. The corresponding RR was 1.17 (CI 0,85-1,61). [30] This is in contrast to a previous study found RR 0.63 indicates nearly half of the risk with a diet high in boron. [31]


9.3. Bladder and urinary tract

Letter to the editor Journal of Medicine Head of Complementary and Alternative makes note of the small study with 14 participants. [32] 10 mg of boron per day given to people with confirmed urolithiasis (kidney stones) and patients tend to report on the reduction of pain after 2-3 days of treatment and many patients reported a few weeks pass kidney stones from treatmetn. It was time to pass the kidney stones very variable. [32]

Preliminary evidence that boron can help in the secretion of kidney stones and pain associated


10. interactions elements nutritious food

10.1. Vitamin D

Boron supplements interact with the metabolism of vitamin D. [33] Examples include poor diet boron (marginal magnesium and copper) reduce vitamin D levels to 25 hyroxyvitamin 44.9nM D after 63 days but increased again after 49 days of renewal with 62.4nM 3 mg of boron [34] and intervention using fructoborate 6 mg (boron fruit storage control), an increase of 20% in the 25-hydroxy vitamin D in vitamin D deficient individuals, and was told that is not due to seasonal fluctuations. [33]

Currently mechanisms, has proved these observations. Author assumed that boron may interact with metabolite of vitamin D to form a competitive inhibitor of 24-hydroxylase, an enzyme in the synthesis of vitamin D, or inhibition of the enzyme directly. [33] This hypothesis "has not been tested.

It seems to raise the mediator between vitamin D3 and vitamin D3 hormonally active product levels, by an unknown mechanism

Bio X4 Safety and Toxicology

11.1. Public

The top limit set (TUL) boron in 20 mg per day for people over the age of 18 [35] This is not a little higher limits can be harmful to the Supreme observed (NOAEL) of 17.5 mg on the basis of studies on mice. [36]

] That there is no clear evidence of testicular damage from excessive exposure to boron, which is in contrast to many food metals has been observed [37. Water levels are not linked to from 6.5 mg / L in boron mining area with damage testis [38] and when confirmed serum levels in 499.2ppb and concentrated in semen any parameters negative damage sperm [39] and has been observed in the cohort with average 14.45mg per day, with a group 30 mg amount is higher. [36]

Spread this lack of toxic effects on the testes to mice that received 500 ppm daily for 60 days, although 1000-2000ppm associated with the accumulation of testicular boron and testicular atrophy. Been replicated [29] These effects in rats exposed to 1173 mg for 90 days. [40]

Testicular damage excess levels of boron, appears to be three times higher, at least from a record supplementary doses, and probably not a concern with the appropriate supplements

11.2. Acute toxicity of boron

It said (quoted no studies) that oral doses of 5-6g Burrow (5,000-6,000mg) in infants or in adults 15-20g (15,000-20,000mg) cause acute death in humans. [29]

Boron, which is used in pesticides, has some information on the toxicity of animals that are exposing boron dramatically.