P- glycoprotein inhibitors may increase the bioavailability of Icariin

Nutrient nutrient interactions 7.

Nucific Bio X4. Yohimbine

Yohimbine has also been investigated in their properties as erectogenic (pills erection). A study in yohimbine and sildenafil (Viagra), which engages in the same PDE5 inhibitory mechanism as Icariin, they were synergies in terms of increasing pressure between the grooves and erection. [44]

And Yohimbine theoretically that horny goat weed may be proerectile synergies, but this did not prove directly

7.2. P-glycoprotein

Scri- P protein as ecdysteroid or pepper carotenoids are capable of inhibiting protein capital known as P- glycoprotein escape. This efflux protein is responsible for the expulsion of icariin in the intestinal lumen after it has been absorbed [8], which is also the main route of excretion when connected to the yellow acids to prevent absorption. [14] coingestion of Icariin with inhibitor for P- glycoprotein increases the AUC of Icariin, and perception can increase the biological activity of Icariin (although this has not been proven). [14]

P- glycoprotein inhibitors may increase the bioavailability of Icariin


8. Safety and Toxicity
Was making any specific toxicology studies on icariin, despite the fact that the highest dose tested in mice at the present time is 200 mg / kg of body weight icariin for 7 days did not show any clinical signs of toxicity.


8.1. Case studies

A case study where the old man of 66 years was published suffering from hypomania (euphoria and anger constantly state of mind) and Altsraei arrhythmia (abnormal heart rhythm and increased heart rate) associated with horny goat weed. Signed [45] side effects after two weeks of supplementation (brand undeclared and dose), and it includes drugs coingested beta blockers, statins, aspirin and Viagra. The theme of bipolar disorder not otherwise provided for by the appearance of results. [4. 5]

Another study looked at the case of benign skin rash develops after ingestion or horny goat weed and gingko biloba. Having taken both at the same time, so it is not certain that the shares or whether the combination is the reason. Was [46] the subject and take oral compounds healthy 77 years.