Horny Goat Weed Summary (All / effects / data and information is essential benefits)

Nucific Bio X4 Horny Goat Weed

Summary (All / effects / data and information is essential benefits)

Horny goat weed is an herb (Epimedium), which is characterized as an aphrodisiac and is described as testosterone. Drift simple names of goats and sheep, who served a little more frisky after eating Epimedium which grew near their fields.

Also sometimes it referred to by the active ingredient, icariin. It is known Icariin prenylated flavonoid compound has been shown to exert the most sexy aphrodisiac effects of horny goat weed. It has also been shown in a study on mice to increase testosterone levels in higher doses, and moderate doses is shown to be beneficial for bone health.

Icariin does not appear to increase testosterone in women, but two other vehicles in the horny goat weed (Icaritin, Desmethylicaritin) increase estrogen in postmenopausal women. Herb acts as an aphrodisiac for both sexes, increasing the type and specific hormone can be beneficial for both sexes.



What You Should Know
Also known as

Epidemium, escape Epimdii, Icariin, Yinyanghuo, fairy wings, raucous carry Herb


Not to be confused with

Icariin (active ingredient)


Things to consider

Icariin is not encouraging.
Icariin his pro-erectile dysfunction in men and properties seen as a libido enhancer for both sexes

Taking (the recommended dose, active and quantities, and other details)
Increase testosterone effects in mice at a dose of 200 mg / kg have been observed from an extract of 40% (80 mg / kg icariin), and transfers based on the body weight of mice to humans [36] This results in the human dose estimated:

Icariin 900 mg someone £ 150
Icariin 1200 mg someone £ 200
Icariin 1500 mg someone £ 250
Studies using a lower dose of icariin (1-10 mg / kg) almost equal:

11-110mg Icariin someone £ 150
15-150mg Icariin someone £ 200
18-180mg Icariin someone £ 250
The human study in postmenopausal women and bone health 60mg daily Icariin was active, and can serve as a less effective dose currently known. Also it appears to be within the scope of the above less active than mice show benefits doses.
1. Composition and structure

Eleven. Installation

Horny Goat Weed is the common name for the plant genus Epimedium of Berberidaceae family. When it sold as a supplement, a unified content Icariin, which is seen as an active ingredient.

Sex contain Epimedium (specific plants in brackets):

Icariin, diglycosdie prenylated flavonoids known as the active ingredient [2]
Structurally similar compound icariin, exacerbating Epimedium A, B and C [2]
Quercetin [2]
Ikarioside A and B (wanshanense) [2]
Anhydroicaritin and Desmethylanhydroicaritin (wanshanense) [2]
Sagittatoside B (wanshanense) [2]
Diphylloside A and B (wanshanense) [2]

1.2. Structure

It is known Icariin as "diglycoside prenylated of Kaempferol. Specifically, the infrastructure has Kaempferol group prenyl- attached to the molecule (as described below, tail left over is the start of a pistol) and two sugar molecules attached to it. One molecule of glucose and one molecule from R2 R1 in rhamnose. Three other popular molecules in horny goat weed, Epimedin AC have the same backbone but only after suffering various sugars in R1 and R2.



Icariin have a molecular weight of 676.67 g / Mall. [3]

Similar compounds have complex Icaritin presence OH group in which each of sugars would coexist (R1, R2) and the presence of Desmethylicaritin OH group in all positions R. Each of these compounds are in horny goat weed plant. [4] [2]

Bio X4. Pharmacy

21. intestinal absorption

Icariin is not a stable compound in the human intestine because these enzymes. Icariin, along with three other complexes mother's original horny goat weed (Epimedin A, B and C), flavonoids and prenylated, are digested quickly in plant metabolism all of them in the intestinal environment by decomposition. It seems that these four vehicles to be mostly sugar rhamnose cleaved during this process. [5] Co-ingestion of lactase florizine hydrolase (lactase) inhibitor increase the absorption of active ingredients, and maintain 40-62% of the original content of icariin. [6] without mentioning inhibitor of lactase, bioavailability respectively about 12% icariin. [7]

Baohuoside metabolism first icariin, which is the same structure but with a smaller portion of glucose. Loss of glucose part can more than double the intestinal membrane movement. [8] baohuoside absorption (and related compounds) is the second fast flow out into the light, and active transport mediated by MRP2 and BCRP (breast cancer resistance protein). MRP2 inhibition may increase the absorption of the first baohuoside. [8] can possibly be overridden these receptors, such as increasing the efficiency of concentration reduces baohuoside I efflux. [8] When the intestine, Baohuoside I appear to be the metabolism is not due to an obvious lack of appropriate glycosidases intestine (in the laboratory, rats). [9] [8]

Icariin flow of the intestinal wall into the light occurs via efflux pump P- glycoprotein. [8]

The poor to some extent of absorption in the intestine, but it seems promising to combine icariin with P-glycoprotein inhibitors such as ecdysteroids or MRP2 inhibitors in terms of metabolism of icariin, Baohuoside I

2.2. Colon

Icariin, if not absorbed, can be sent to the colon and prevent bacteria through Icariside II, a compound potentially erectogenic of icariin. [10]


2.3. Regularity

After eating intravenously in mice, icariin 10 mg / kg of body weight may average - / - 0.562 +/- 0.2 hours of life and the elimination rate constant (Ke) of 1.361+. 0.556 1 / h [11] Another study use. Icariin at the same dose by injection, however, note a half life of 75.1 hours of 170 +/- propose some variation (Yi et al. 1999). [12]

After oral ingestion of 4.5 mg / kg in mice icariin on Cmax 3.37 +/- 1.42mg / L, which AUC of 40.6 +/- 5.73mg / h / L with a half-life is seen to 10.9 +/- 1.35 hours. The elimination rate constant is 0.064 +/- 0:11 / h. [13]

A study on horny goat weed dosed at 1.64 g / kg (4.38mg / kg icariin) Cmax showed oral administration of 2.41 +/- 0.2mcg one / ml, a AUC of 23.62 +/- 1.37mcg / h / ml and TMAX 1.55 + / - 0:53 hour and a half life of 0.11 +/- 0.07 hours [7] also compared this study eat horny goat weed against a combination of two other herbs HGW (Nepal due to dock and Ficus hirta ignorance;. three main components in Chinese medicine) and found that the Cmax of Icariin was higher (3.13 +/- 0.29μg / ml), and the American University in Cairo (30.84 + / - 3.68mcg / h / ml) half-life (0.35 +/- 0.32 hours), and it was a long time TMAX (2.06 +/- 0.15 hour) when coingested. [7] Do not know what compound in a mixture of eight herbs to improve the image of the pharmaceutical Icariin.

Another Chinese herbs that provide horny goat weed mixture (BAA Xian) to 4.8 g / kg orally, measurement parameters (Cmax, AUC, half life is consistent and the judiciary) is not up to the level of 4.5 mg / kg icariin, however, it seems to increase the absorption of icariin just as horny goat weed is composed of 19% by weight of the mixture and the results were quite similar. [13]

The profile of the pharmaceutical Icariin seems to be useful are affected by some herbs or herbal ingredients simply we do not know precisely what.

2.4. Secretion

The main metabolic path of Icariin seems to gall bladder secretion, or output Icariin with bile salts in the intestinal lumen to go out in the stool. [14] coingestion of P-glycoprotein inhibitors can reduce the elimination of icariin, [14], and possibly by inhibiting the flow of the intestine above production. [8] [15]